相关实验视频

Updated: Jul 18, 2025

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

糖化纤维素改善了第一季度预测子宫前的预测

S Moungmaithong¹, X Wang², C S L Lau²

¹Department of Obstetrics and Gynaecology, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology

|August 24, 2023

概括

在胎儿医学基金会 (FMF) 三重测试中添加糖化纤维素 (GlyFn) 显著改善了亚洲女性的妊娠前 (PE) 查敏感性. 这种增强的查有助于早期检测早产和随时发病的PE.

科学领域:

生殖医学和产科生殖医学
发现怀孕并发症的生物标志物

背景情况:

孕前 (PE) 是孕产妇和胎儿发病的主要原因之一.
在第一季度对PE的查对于及时干预至关重要.
胎儿医学基金会 (FMF) 三重测试是一种常见的查工具.

研究的目的:

评估母体血清糖化纤维素素 (GlyFn) 是否提高了FMF三重测试对PE查的敏感性.
为了评估GlyFn在亚洲人群中的有效性.

主要方法:

一个嵌套的病例控制研究,涉及1685名中国怀孕 (11-13周怀孕).
使用ELISA和护理点 (POC) 设备测量GlyFn.
使用GlyFn和没有GlyFn的查性能 (AUC,DR在10%的FPR) 的比较,使用FMF竞争风险模型.

主要成果:

与非PE怀孕相比,在早产和长期PE怀孕的怀孕中,GlyFn水平显著升高.
将GlyFn添加到FMF三重试验中显著增加了早产PE的AUC,从0.859增加到0.896.
过早发育前期的检测率从64.9%增加到82.9%,随时发育前期的检测率从52.5%增加到65.4%,FPR为10%.

结论:

孕产妇血清GlyFn显著提高了在亚洲人群中查子前期症的FMF三重测试的灵敏度.
格莱芬是一种有前途的生物标志物,可以提高PE的早期检测,特别是早产PE.
建议进行进一步的前性研究来验证这些发现.

关键词:

胎儿医学基金会胎儿医学基金会美国PlGFF 竞争风险模型的竞争风险模型内皮细胞生物标志物生物标志物第一个三个月的查.糖化纤维素结核蛋白 (Glycosylated Fibronectin) 是一种糖化纤维素结核蛋白.平均动脉压力是指动脉的压力.胎盘生长因子胎盘生长因子医疗服务中心的设备.孕前,也就是孕前.子宫动脉多普勒对象

更多相关视频

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Chemically-blocked Antibody Microarray for Multiplexed High-throughput Profiling of Specific Protein Glycosylation in Complex Samples

Published on: May 4, 2012

Mouse In Vivo Placental Targeted CRISPR Manipulation

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

相关概念视频

Fibronectins Connect Cells with ECM

Fibronectins Connect Cells with ECM

Fibronectin is an adhesive glycoprotein present in the extracellular matrix of embryogenic and adult tissue. These molecules primarily aid in regulating cell motility and attachment. A fibronectin molecule is composed of two identical polypeptide chains attached to each other by a pair of disulfide bonds at the C-terminal.
Both proteoglycans and collagen are attached to fibronectin proteins, which, in turn, are attached to integrin proteins. These integrin proteins interact with transmembrane...

Transcytosis of IgG

Transcytosis of IgG

Transcytosis is the process in which molecules are internalized by endocytosis, transported across the cell, and released through exocytosis from the opposite end of the cell. Molecules such as insulin, immunoglobulins, and certain nutrients are transferred through the recycling endosomes by recycling and transcytosis.
IgG molecules from a mother undergo transcytosis starting around 13 weeks of gestation. The amount of IgG transferred and entering the fetal blood circulation increases with...