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Cdc73保护诺奇诱导的T细胞白血病细胞免受DNA损伤和线粒体应激

Ashley F Melnick1, Carea Mullin2, Karena Lin1

  • 1Cellular and Molecular Biology Program, University of Michigan School of Medicine, Ann Arbor, MI.

Blood
|August 24, 2023
PubMed
概括

细胞分裂周期73 (Cdc73) 通过与Notch信号交互,对T细胞急性淋巴细胞白血病 (T-ALL) 至关重要. 准Cdc73提供了一种针对T-ALL的新策略,绕过了Notch抑制剂的毒性.

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