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完全闭环血糖控制与胰岛素疗法相比,在1型糖尿病和低于最佳血糖控制的成年人中进行持续血糖监测:单中心,随机,交叉研究
Charlotte K Boughton1,2, Sara Hartnell2, Rama Lakshman1
1Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, U.K.
Diabetes care
|August 24, 2023
概括
使用超快速胰岛素lispro的完全闭环胰岛素输送显著改善了1型糖尿病成年人的葡萄糖控制. 这种先进的系统的性能优于传统的胰岛素疗法与持续血糖监测 (CGM).
科学领域:
- 内分泌学 在内分泌学.
- 生物医学工程 生物医学工程
- 糖尿病 技术 技术
背景情况:
- 在1型糖尿病 (T1D) 中,低于最佳的血糖控制需要先进的治疗策略.
- 持续血糖监测 (CGM) 的胰岛素治疗是标准的,但在T1D管理方面正在寻求改进.
- 完全闭环系统提供自动胰岛素输送,可能提高血糖结果.
研究的目的:
- 评估使用超快速胰岛素lispro的完全闭环系统的安全性和有效性.
- 为了比较这种闭环系统与标准的胰岛素疗法,在T1D和低于最佳血糖控制的成年人中使用CGM.
主要方法:
- 采用了一个单中心,随机,交叉研究设计.
- 26名T1D和HbA1c≥7.7%的成年人参与了这项研究,他们使用胰岛素疗法与低于最佳的血糖控制.
- 参与者经历了两次8周的时间,将CamAPS HX完全闭环系统与他们通常的胰岛素和CGM进行了比较.
主要成果:
- 完全闭环系统显著增加了葡萄糖范围中的时间 (50.0%对36.2%,P<0.001).
- 闭环治疗减少了高血糖 (葡萄糖>10.0 mmol/L) 和平均葡萄糖水平的时间.
- 没有报告严重的低血糖或糖尿病酸事件,每日总胰岛素需求仍然相当.
结论:
- 使用CamAPS HX系统提供完全闭环胰岛素,在T1D成年人中显示出优越的葡萄糖控制和低于最佳的血糖控制.
- 这项技术为使用CGM的传统胰岛素治疗提供了安全有效的替代方案.
- 这些发现支持采用先进的自动化胰岛素输送系统,以改善T1D管理.
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