在绝经前和绝经后妇女的性功能激素治疗
Lucia A Lara1, Denisse Cartagena-Ramos2, Jaqueline Bp Figueiredo1,3
1Department of Obstetrics and Gynecology, Medical School of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil.
The Cochrane database of systematic reviews
|August 24, 2023
概括
仅使用雌激素的激素治疗可能会改善绝经后妇女的性功能,特别是在滑和满足方面. 其他激素疗法的证据仍然不确定,因为研究质量不佳.
科学领域:
- 生殖医学 生殖医学
- 妇女健康 妇女健康
- 药理学 药理学是指药理学的学科.
背景情况:
- 绝经,包括绝经前期和绝经后阶段,通常伴有各种症状,特别是性投诉.
- 这篇综述是对2013年之前关于这个主题的出版物的更新分析.
研究的目的:
- 评估激素疗法 (HT) 对经历半绝经和绝经后妇女的性功能的影响.
主要方法:
- 进行了随机对照试验 (RCT) 的系统审查和元分析.
- 在多个数据库中进行了搜索,直到2022年12月,包括参考检查和专家咨询.
- 包括的RCT比较了各种形式的HT (仅雌激素,雌激素与孕激素,提博,SERM) 与安慰剂或没有干预,使用验证的工具评估性功能.
主要成果:
- 包括36项涉及23299名女性的研究;35项专注于绝经后妇女.
- 雌激素单独可能为症状/早期绝经后妇女 (中等质量证据) 和未选择的绝经后妇女 (中等质量证据) 的性功能综合评分略有改善.
- 对雌激素结合孕激素,合成类固醇和选择性雌激素受体调节器 (SERM) 对性功能的疗效的证据质量非常低,导致对其影响的不确定性.
结论:
- 雌激素单独的激素治疗似乎对绝经后妇女的性功能提供了适度的好处,特别是在滑,疼痛和满意度方面.
- 综合激素疗法,合成类固醇和SERM对性功能的影响仍然在很大程度上不确定,因为缺乏高质量的证据.
- 需要进一步进行高质量的研究,以澄清各种激素疗法的有效性,以改善绝经前和绝经后妇女的性功能.
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