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相关概念视频

Polymer Classification: Architecture01:14

Polymer Classification: Architecture

2.8K
Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
2.8K
Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

2.5K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
2.5K
Polymers: Molecular Weight Distribution01:10

Polymers: Molecular Weight Distribution

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For any given polymer, the weight average molecular weight (Mw) is higher than, if not equal to, the number average molecular weight (Mn). The only situation in which the weight average molecular weight and the number average molecular weight are equal is when a polymer consists only of chains with equal molecular weight. However, this never happens in a synthetic polymer, since it is difficult to control the polymerization process up to a molecular level with accuracy to a hundred percent.
3.5K
Radical Chain-Growth Polymerization: Chain Branching01:17

Radical Chain-Growth Polymerization: Chain Branching

2.0K
The skeletal structure of polymers synthesized via radical polymerization is always branched. For example, the polymerization of ethylene by radical polymerization results in a low-density grade of polyethylene with a heavily branched skeletal structure. Here, the radical site abstracts hydrogen from the growing chain, and the radical site shifts from the end (a primary carbon center) to anywhere within the growing chain (a secondary carbon center). Consequently, the part of the chain from the...
2.0K
Ziegler–Natta Chain-Growth Polymerization: Overview01:17

Ziegler–Natta Chain-Growth Polymerization: Overview

3.4K
Ziegler–Natta polymerization is another form of addition or chain‐growth polymerization used for synthesizing linear polymers over branched polymers. The catalyst used for polymerization is the Ziegler–Natta catalyst, named after Karl Ziegler and Giulio Natta, who developed it in 1953. This catalyst is an organometallic complex of titanium tetrachloride and triethyl aluminum, with the active form of the catalyst being an alkyl titanium compound. Using the Ziegler–Natta...
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Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

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The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
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相关实验视频

Updated: Jul 18, 2025

Polymer Microarrays for High Throughput Discovery of Biomaterials
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Polymer Microarrays for High Throughput Discovery of Biomaterials

Published on: January 25, 2012

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探索多重复的外界限制.

A Agrawal1, Q Leng1, Z Imtiyaz1

  • 1Department of Pathology, University of Maryland School of Medicine, 10 S. Pine St., University of Maryland, Baltimore, MD, 21201, USA.

Biochemical and biophysical research communications
|August 24, 2023
PubMed
概括

松散包装的histidine-lysine多重复合体显示出在体内有效的瘤传染的前景. 低/DNA比率增强瘤传染和特异性,克服了以前多重复合配方的局限性.

科学领域:

  • 生物技术是生物技术.
  • 基因治疗 基因治疗
  • 聚合物科学 聚合物科学

背景情况:

  • 含有histidine的聚合物正在探索用于核酸输送.
  • 多复合体经常通过EPR效应在瘤中积累,临床成功有限.
  • 神经皮林-1介导的运输是改善分娩的目标.

研究的目的:

  • 比较两种histidine-lysine (HK) 多复合体在体内进行等离子体输送.
  • 评估酸/DNA比对瘤转移和特异性的影响.
  • 研究多重复结构和转化效率之间的相关性.

主要方法:

  • 在体外和体内对聚合HK (H2KC-48) 和单体HK (H2K) 复合物的比较.
  • 在瘤异种移植中评估等离子体转染.
  • 电泳凝阻滞试验用于分析多重复结构.

主要成果:

  • 这两种HK多重复体都在体内表现出有效的瘤异种移植转移.
  • 较低的/DNA比率导致较高的瘤传染和特异性.
  • 对于低/DNA比率的多重复合体,观察到最小的凝延迟,表明松散包装.
关键词:
希斯蒂迪因 (Histidine) 是一种胺.这是一种类.塑体 塑体 塑体多重复合体是一种多重复合体.瘤是一个瘤.

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Assembly and Characterization of Polyelectrolyte Complex Micelles

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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

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相关实验视频

Last Updated: Jul 18, 2025

Polymer Microarrays for High Throughput Discovery of Biomaterials
13:37

Polymer Microarrays for High Throughput Discovery of Biomaterials

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Assembly and Characterization of Polyelectrolyte Complex Micelles
08:44

Assembly and Characterization of Polyelectrolyte Complex Micelles

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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level
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Synthesis of Cyclic Polymers and Characterization of Their Diffusive Motion in the Melt State at the Single Molecule Level

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结论:

  • 松散包装的HK多复合体在体内瘤转移方面是有效的.
  • 优化/DNA比率对于提高转染效率和特异性至关重要.
  • 这项研究突出了一个有前途的策略,用于将基因传递到瘤中.