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童年创伤和社会支持通过大抑郁症中皮质厚度异常影响症状概况:结构方程建模分析
Chenguang Jiang1, Wenhao Jiang1, Gang Chen2
1Department of Psychosomatics and Psychiatry, ZhongDa Hospital, School of Medicine, Southeast University, Nanjing, China.
Asian journal of psychiatry
|August 24, 2023
概括
童年创伤和较低的社会支持与严重抑郁症 (MDD) 中的大脑结构变化有关. 这些因素通过影响特定的大脑区域,如PCC和MTG,影响情绪和自杀念头.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 脑部成像 脑部成像
背景情况:
- 大型抑郁症 (MDD) 与童年创伤,低社会支持和alexithymia有关.
- 将这些风险因素与MDD症状和大脑异常联系在一起的确切机制尚不清楚.
- 结构方程建模 (SEM) 是分析复杂相互关系的宝贵工具.
研究的目的:
- 为了研究风险因素 (童年创伤,社会支持,alexithymia) 和MDD的临床表型之间的关系.
- 通过使用SEM识别与这些风险因素相关的特定结构性大脑异常.
- 阐明大脑结构在MDD症状表现中的调解作用.
主要方法:
- 313名被诊断为MDD的患者接受了磁共振成像 (MRI).
- 参与者完成了儿童创伤,alexithymia,社会支持,anhedonia,抑郁症,焦虑和自杀念头的评估.
- 采用多变量SEM,将皮质厚度数据与临床和风险因素变量结合起来.
主要成果:
- 在SEM分析中,风险因素与皮层厚度之间存在显著的相关性.
- 童年创伤与左侧中旋 (MTG) 皮质厚度负相关.
- 社会支持与左后带状皮层 (PCC) 皮层厚度负相关.
- 该SEM模型表明,左PCC厚度介导了社会支持和自杀念头之间的联系.
- 发现左MTG厚度调解了童年创伤和无情/焦虑之间的关系.
结论:
- 这些发现支持风险因素对大脑结构和MDD的临床表现的影响.
- 不充分的社会支持和童年创伤可能会导致PCC和MTG分别出现皮质异常.
- 这些结构变化似乎影响了MDD患者的情绪调节和自杀念头.
- 针对PCC和MTG可能是MDD的未来治疗策略.
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