赫西丁和醇对表面的Candida生物膜的协同作用
Heng Zhang1, Xuesong Yi2, Mei Chen1
1Department of Dermatology, Jingzhou Hospital Affiliated to Yangtze University, Jingzhou, Hubei, China.
Journal de mycologie medicale
|August 24, 2023
概括
一种新的药物组合有效地准了骨科植入物上的Candida生物膜. 赫西丁 (CHL) 与醇具有很高的协同作用,为挑战植入物相关感染提供了有希望的治疗方法.
科学领域:
- 整形外科 整形外科 整形外科
- 传染性疾病 传染性疾病
- 生物材料是一种生物材料.
背景情况:
- 由Candida引起的骨科植入物感染是治疗结果不佳的严重并发症.
- 植入物上的Candida生物膜对标准的抗真菌药物表现出耐药性.
- 开发针对这些生物膜的新型治疗策略至关重要.
研究的目的:
- 为了研究赫西丁 (CHL) 与醇抗真菌剂相结合的对骨科植入物材料上的Candida生物膜的协同效果.
- 评估这种组合作为骨科植入物相关的Candida感染的潜在治疗方法.
主要方法:
- 培养了26种临床Candida分离物,在和非表面形成生物膜.
- 采用了棋盘方法来评估CHL和阿醇 (可纳,伊特拉可纳,沃里可纳) 之间的协同作用.
- 利用细胞活力测定和CFU减小来量化生物膜抑制.
主要成果:
- 在实验室中,CHL与可纳 (61%),伊特拉可纳 (65%) 和伏利可纳 (23%) 对Candida生物膜表现出协同作用.
- 单独使用CHL疗法显著抑制了板上的生物膜形成.
- 结合CHL和弗卢科纳可实现100%的协同作用,与上的生物膜相抗衡,将最小抑制度降低4-8倍.
结论:
- 赫西丁与醇结合,可以有效地抑制骨科植入物材料上Candida生物膜的形成.
- 这种组合疗法在管理和治疗骨科植入物相关的Candida感染方面具有显著的潜力.
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