一项随机临床试验,以支持患者儿童的坚持治疗方案:检查潜在的变化机制
Adrien M Winning1, Constance A Mara2, Desireé N Williford1
1Behavioral Medicine and Clinical Psychology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA.
Epilepsy & behavior : E&B
|August 24, 2023
概括
与单独的教育相比,支持治疗坚持方案 (STAR) 干预措施并没有显著改善的知识或解决问题的技能. 这些因素并没有调解患者年轻人坚持改善的情况.
科学领域:
- 儿科神经学 儿科神经学
- 行为科学 行为科学
- 医疗保健服务研究 医疗服务研究
背景情况:
- 药物坚持对于治疗儿童至关重要.
- 支持治疗坚持方案 (STAR) 干预方案是为了改善患者年轻人坚持治疗的.
- 之前的RCT结果显示,与仅教育 (EO) 相比,STAR的遵守率提高了21%.
研究的目的:
- 为了检查STAR是否影响知识,坚持障碍,解决问题,照顾者痛苦和家庭功能.
- 为了确定这些因素是否调解了12个月后STAR和EO组之间的坚持差异.
主要方法:
- 200名患有的儿童 (2-12岁) 和护理人员参加了RCT.
- 参与者被随机分配到STAR或EO干预.
- 通过多个时间点的问卷来评估结果;使用纵向模型.
主要成果:
- 随着时间的推移,大多数结果中没有发现任何显著的群体差异.
- 社会问题解决技能最初在STAR组中较高,但随着时间的推移而下降.
- 没有任何一个被检查的因素调解了群体依从性差异.
结论:
- 为了提高坚持,STAR干预的机制需要进一步研究.
- 无意义的发现强调了需要改进的研究设计和干预措施的需要.
- 未来的研究应该探索治疗改变的替代媒介.
更多相关视频
10:02Event Related Potentials ERPs and other EEG Based Methods for Extracting Biomarkers of Brain Dysfunction: Examples from Pediatric Attention Deficit/Hyperactivity Disorder ADHD
Published on: March 12, 2020
15.7K
10:46Author Spotlight: Obtaining High-Quality CSF and Blood Samples for Epilepsy Biomarker Discovery
Published on: September 1, 2023
3.1K
相关概念视频
01:11Clinical Trials: Overview
3.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
3.0K
01:16Clinical Trials
6.8K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
There are four phases in a clinical trial. A phase one...
6.8K
01:28Drug Therapy
68
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
Antianxiety Medications
68
01:24Arteries of the Lower Limbs
213
Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...
213
01:11Blinding
2.5K
Blinding is a commonly used method of not telling participants which treatment a subject is receiving. Blinding is a critical part of a randomized control trial or RCT. It reduces the bias that affects the results. In an RCT, blinding is used in the form of a placebo. A placebo effect occurs when untreated subjects falsely believe they have received the treatment and report improved symptoms. A placebo or a dummy treatment is administered to subjects to negate the bias caused by such an effect.
2.5K