描述生活方式因素和结构性大脑措施之间的共变性模式:两个独立的衰老队列的多变量复制研究
Naiara Demnitz1, Oliver J Hulme2, Hartwig R Siebner3
1Danish Research Centre for Magnetic Resonance, Centre for Functional and Diagnostic Imaging and Research, Copenhagen University Hospital-Amager and Hvidovre, Hvidovre, Denmark.
Neurobiology of aging
|August 24, 2023
概括
健康老龄化涉及多种生活方式因素,而不仅仅是一个. 这项研究使用多变量分析来探索生活方式选择与老年人大脑结构之间的联系,发现了积极的相关性.
科学领域:
- 神经科学是一个神经科学.
- 老年学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 可修改的生活方式因素被认为有助于促进健康的大脑衰老.
- 之前的研究经常孤立地检查单一的生活方式因素.
- 多变量方法提供了一个更现实的生活方式-大脑关系模型.
研究的目的:
- 调查多种生活方式因素与大脑结构指数之间的关系.
- 应用正统相关性分析 (CCA) 来建模生活方式与大脑的联系.
- 在独立的队列中验证发现.
主要方法:
- 使用正规相关性分析 (CCA) 检查9个生活方式因素和7个MRI衍生脑结构指数之间的关联.
- 用贝叶斯回归来进一步探索已识别的协差模式.
- 这项研究涉及两个队列:丹麦老年人 (n=251) 和英国队列 (n=668).
主要成果:
- 在两个队列中,潜伏生活方式和大脑结构因素之间观察到显著的正相关性 (英国:r=0.37,p<0.001;丹麦:r=0.27,p<0.001).
- 交叉验证结果的相关性为r=0.10 (p=0.008).
- 生活方式因素和大脑结构之间的特定关联模式在数据集之间有所不同.
结论:
- 多变量生活方式因素与老年人大脑结构有积极的关联.
- 观察到的生活方式与大脑的关联在不同人群中并不统一.
- 根据基线样本特征定制生活方式干预措施可能会提高健康大脑衰老的有效性.
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