男人年龄对父亲形状的影响:单核酸多态化微阵列结果在母细胞囊活检后
Tanya Samarasekera1, Elissa Willats2, Mark P Green3
1Monash IVF, Melbourne, Australia..
Reproductive biomedicine online
|August 24, 2023
概括
先进的父亲年龄 (≥40岁) 不会增加来自精子的胚胎积体的风险. 植入前遗传测试可能不仅仅是基于父亲的年龄.
科学领域:
- 生殖医学 生殖医学
- 遗传学 遗传学 是一个
- 胚胎学 胚胎学
背景情况:
- 先进的父亲年龄 (APA),定义为40岁或以上的父亲年龄,是生殖医学中日益关注的问题.
- 对APA对精子质量和产生的胚胎遗传完整性的潜在影响需要彻底调查.
研究的目的:
- 调查先进的父亲年龄 (APA) 是否与在人类植入前胚胎中增加父系形发病率有关.
- 为了确定APA是否会影响来自父性雌同体的全染色体或细分质瘤的发生率.
主要方法:
- 一项多中心的回顾性研究分析了使用单核酸多态化 (SNP) 微阵列的胚胎胚胎的植入前遗传测试 (PGT) 结果.
- 来自681个辅助生殖技术 (ART) 周期的数据,涉及389名男性患者 (2012-2021年),分析了全染色体无化,以及涉及140名男性的242个周期 (2016-2021年) 的细分无化.
- 胚胎根据父亲的年龄 (<35,35-39岁和≥40岁) 进行分类,并比较了父亲和母亲的血管积分率.
主要成果:
- 在父子年龄组之间没有观察到父子起源全染色体积病率的显著差异 (P=0.7561).
- 孕产妇出生的无体积症的发病率在各组之间有显著差异 (P<0.0001),与孕产妇的年龄相关.
- 父源删除比母源删除更常见 (P=0.0084),但APA没有显著增加删除率 (4.8%对2.5-2.8%,P=0.5292).
结论:
- 先进的父亲年龄 (≥40岁) 与在植入前胚胎中增加的父系无体积发病率没有显著关联.
- 这些发现表明,单独的APA可能不是植入前遗传测试 (PGT) 的充分指示.
- 进一步的研究可能是有必要的,以探索其他潜在的与父亲年龄相关的对胚胎发育的影响.
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