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与喘单独相比,喘-COPD重叠的患者中疹性中耳炎的发病率和严重程度更高
Emiri Sato1, Yukako Seo2, Etsuko Tagaya3
1Department of Otorhinolaryngology, Tokyo Women's Medical University, Tokyo, Japan, sato.emiri@twmu.ac.jp.
International archives of allergy and immunology
|August 24, 2023
概括
喘-COPD重叠 (ACO) 在慢性鼻炎患者中增加了异性中耳炎 (EOM) 的患病率和严重程度. 戒烟和早期ACO治疗可能会减少这些患者的EMO.
科学领域:
- 呼吸系统医学 呼吸系统医学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 炎症研究 炎症研究
背景情况:
- 生性中耳炎 (EOM) 经常与成人发作的喘共存,共享2型炎症途径.
- 喘-COPD重叠 (ACO) 是一种具有较高死亡率的严重疾病,其特征是气道壁加厚 (AWT).
- "一个呼吸道,一个疾病"的概念表明基于喘或ACO并发症的不同EOM病理生理学.
研究的目的:
- 调查EOM病理生理学在慢性鼻炎患者中仅仅是喘患者与伴随性ACO患者的病理生理学不同之处的假设.
- 为了比较喘和ACO组之间的临床特征,EOM患病率,严重程度和中耳溢出 (MEE) 细胞数量.
主要方法:
- 77名患有喘的慢性鼻炎患者被分为仅喘 (46) 和ACO (31) 组.
- 对比包括临床数据,EMO患病率/严重程度,吸烟史 (布林克曼指数),AWT (CT扫描) 和MEE乙烯基蛋白/中性蛋白计数.
主要成果:
- 在ACO组有更多的男性,年龄较大,肺功能较低,吸烟史较高,AWT更高.
- 在ACO组中,EMO患病率和严重程度显著更高,与ACO严重程度相关.
- 与喘组相比,MEE在ACO组中显示出较低的乙氨基粒 (25.3%与54.7%) 和较高的中性粒 (75.7%与41.9%).
结论:
- 喘患者的ACO并发症与EOM患病率和严重程度的增加有关,中耳中性粒细胞透率较高.
- 戒烟和早期ACO干预可以减少AWT的进展,并减轻EOM的患病率和严重程度.
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