创伤后应激障碍的症状与妊娠早期和晚期葡萄糖参数的改变有关
Margaret H Bublitz1,2,3, Micheline R Anderson2,3, Laura Sanapo1,3
1Department of Medicine, Warren Alpert Medical School of Brown University, The Miriam Hospital - Women's Medicine Collaborative, Providence, Rhode Island.
American journal of perinatology
|August 24, 2023
概括
创伤后应激障碍 (PTSD) 的症状与怀孕期间胰岛素分泌量增加有关. 需要进一步的研究来证实这些发现,并探索PTSD治疗方法.
科学领域:
- 产科和妇科 产科和妇科
- 内分泌学 在内分泌学.
- 精神病学是一个精神病学.
背景情况:
- 创伤后应激障碍 (PTSD) 与代谢功能障碍有关,包括胰岛素抵抗和糖尿病.
- 新出现的证据表明,PTSD和妊娠期糖尿病风险之间存在联系.
- 在整个怀孕期间,PTSD对葡萄糖代谢的影响尚不清楚.
研究的目的:
- 调查早期和晚期妊娠中PTSD症状和葡萄糖代谢参数之间的关联.
- 分析PTSD症状如何与妊娠期间的β细胞功能和胰岛素敏感性有关.
主要方法:
- 利用了34名没有先前存在糖尿病的孕妇的数据.
- 在怀孕早期使用DSM-5 (PCL-5) 的PTSD检查清单评估PTSD症状.
- 在怀孕约12周和32周测量了禁食血糖,计算了β细胞功能和胰岛素敏感性.
主要成果:
- 较高的PTSD症状得分与妊娠早期和晚期的β细胞功能增加有关.
- 调整后的分析控制了母亲的年龄,种族,种族,BMI,呼吸暂停低呼吸指数和抑郁症状.
- 在PTSD症状和胰岛素抵抗之间没有发现显著的关联.
结论:
- 增加的PTSD症状与整个怀孕期间更大的胰岛素分泌相关.
- 这些发现突显了PTSD和妊娠期间改变的葡萄糖代谢之间的潜在联系.
- 需要进一步的研究来验证这些结果,并检查PTSD治疗在减轻妊娠糖尿病风险方面的作用.
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