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对肺癌,直肠癌,前列腺癌和宫癌的最佳辐射疗法利用率的年龄和并发症调整的发展

Penny Mackenzie¹, Claire Vajdic², Geoff Delaney³

¹Collaboration for Cancer Outcomes Research and Evaluation (CCORE), The University of New South Wales, Sydney, Australia; The Royal Brisbane and Women's Hospital, Queensland, Australia.

Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology

|August 24, 2023

概括

在老年癌症患者中,最佳放射治疗利用率 (RTU) 低于预期,即使考虑到年龄和并发症. 需要进一步的研究来理解和解决RTU中的这些差异,以改善癌症护理.

科学领域:

在瘤学瘤学.
放射治疗利用辐射疗法
老年医学老年医学

背景情况:

最佳放射治疗利用 (RTU) 模型对于估计从放射治疗中受益的癌症患者比例至关重要.
以前的模型没有考虑伴随性疾病,这是放射治疗适合性的关键因素,与年龄和预期寿命一起.
本研究通过开发年龄和并发性疾病调整后的RTU模型来弥补这一差距.

研究的目的:

为肺癌,直肠癌,前列腺癌和宫癌开发一个年龄和并发症调整的最佳RTU模型.
为了将模拟的最佳RTU与实际RTU率进行比较,特别是在80岁及以上的患者中.
确定老年癌症患者在放射治疗获得的潜在差异.

主要方法:

使用了新南威尔士癌症登记,放射治疗和住院数据 (2008-2015).
计算了每个患者的癌症特异性C3"所有部位"并发症指数.
开发了瘤部位特定的决策树模型,包括年龄和并发症数据,以估计最佳的RTU.

主要成果:

分析包括14696名 (NSCLC),1839名 (SCLC),5551名 (直肠癌),30935名 (前列腺癌) 和1216名 (宫癌) 患者.
对于80岁以上的患者,模拟的最佳RTU率在40% (宫) 到51% (前列腺) 之间.
80岁以上患者的实际RTU率低于最佳,除了宫癌 (25%vs40%最佳).

结论:

在老年癌症患者 (80岁以上) 中,实际辐射疗法利用率仍然低于最佳水平,相比以年龄和并发症调整后的最佳率,除了宫癌.
在肺癌,直肠癌和前列腺癌的老年人中,RTU存在显著差异.
需要进一步调查,以了解这些差异的原因,并制定公平辐射治疗准入的战略.

关键词:

宫癌是发生在宫癌的原因之一.老年瘤学老年瘤学肺癌是一种肺癌.前列腺癌是什么意思前列腺癌是什么意思辐射疗法利用的辐射疗法这是直肠癌.

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