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鼻子到大脑输送转移素合PLGA纳米颗粒用于克洛尼丁

Surbhi Sharma¹, Amit Tyagi², Shweta Dang¹

¹Department of Biotechnology, Jaypee Institute of Information Technology, Noida, UP, India.

International journal of biological macromolecules

|August 24, 2023

概括

表面修饰的转林多 (乳酸-co-甘油酸) 纳米颗粒有效地通过鼻子将克洛尼丁输送到大脑. 这些纳米颗粒显示出增强脑药物度和改善小鼠行为反应的有希望的结果.

科学领域:

纳米技术纳米技术
神经科学是一个神经科学.
药理学药理学是指药理学的学科.

背景情况:

鼻至大脑药物输送为针对神经系统疾病的治疗药物提供了直接的途径.
聚乳-同-甘油酸 (PLGA) 纳米颗粒是药物输送的多功能平台.
转移素 (Tf) 修饰可以增强纳米粒子向和细胞吸收.

研究的目的:

开发和表征转移素修饰的PLGA纳米颗粒 (Tf-PLGA-NP) 装载着克罗尼丁 (CLD) 以提高鼻至大脑输送.
评估CLD-Tf-PLGA-NPs的体外和体内性能.

主要方法:

纳米粒子是使用双乳液和溶剂蒸发技术合成的.
特性包括颗粒大小,多分散度指数 (PDI),泽塔潜力和封装效率 (EE%).
在实验室中进行了药物释放,细胞吸收,细胞毒性测定,组织病理学,生物分布和药学动力学研究.

主要成果:

CLD-Tf-PLGA-NPs表现出最佳粒子大小 (199.5 nm),PDI (0.291),以及高EE% (86.2%).
实验室研究表明,具有良好的活力 (61.85%) 的Neuro-2a细胞显著释放药物 (89.54%在PBS中) 和高细胞吸收 (97%).
在体内研究表明,克洛尼丁在大脑中的度增加,小鼠的行为显著改善.

结论:

表面修改的Tf-PLGA-NP是一种可行且有效的系统,用于鼻至大脑输送克洛尼丁.
开发的纳米粒子显示了治疗神经疾病的潜力,改善了治疗结果.

关键词:

细胞吸收的时间克隆尼迪因 (Clonidine) 是一种类型的药物.纳米颗粒纳米颗粒在 PLGA PLGA 中.在转移中转移.

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