持续有机污染物暴露和自闭症谱系障碍的风险:系统性审查和元分析
Kexin Xu1, Zhuoyan Li1, Jianchao Qiao1
1Department of Clinical Medicine, The Second School of Clinical Medicine, Anhui Medical University, 81 Meishan Road, Hefei, 230032, China.
Environmental pollution (Barking, Essex : 1987)
|August 24, 2023
概括
暴露于某些持久性有机污染物 (POP) 可能会增加自闭症谱系障碍 (ASD) 的风险. 具体来说,PCB-138,PCB-153和PCB-170显示出积极的关联,而PFDA显示出与ASD风险的反向关联.
科学领域:
- 环境健康 环境健康
- 神经发育障碍 神经发育障碍
- 毒理学 毒理学 毒理学
背景情况:
- 流行病学研究表明,暴露于持久性有机污染物 (POP) 和自闭症谱系障碍 (ASD) 之间存在联系.
- 现有的研究对这种关联提出了有限且不一致的证据.
- 为了全面了解,需要进一步调查特定的POP及其对ASD风险的影响.
研究的目的:
- 系统地审查和进行对POP暴露与ASD风险之间的关联的元分析.
- 利用现有的流行病学数据,全面调查潜在的联系.
- 评估已识别的关联的证据的强度.
主要方法:
- 在PubMed和EMBASE数据库中进行系统搜索,截至2022年7月3日.
- 在元分析中包含20项研究.
- 分层的随机效应元分析,根据暴露类型和结果推导总结概率比率 (OR) 和95%置信区间 (CI).
- 评估异质性,敏感性分析和出版偏见.
主要成果:
- 对PCB-138,PCB-153和PCB-170的产前暴露与ASD风险增加有关 (ORs从1.46到1.89不等).
- PFDA暴露与ASD风险相反相关 (OR = 0.70).
- 这些关联的证据水平被归类为PCB-138,PCB-153和PFDA的低,PCB-170的中等.
结论:
- 暴露于PCB-138,PCB-153和PCB-170与ASD的风险增加有关.
- 暴露于PFDA似乎与ASD风险相反相关.
- 基于有限的研究结果,这些发现建议谨慎,并强调需要足够强大的研究来验证这些关联.
关键词:
自闭症谱系障碍 自闭症谱系障碍进行元分析分析.perfluoroalkyl 和 polyfluoroalkyl 物质的使用情况.持久性有机污染物 持久性有机污染物聚化二乙烯乙烯的多化二乙烯.聚化双烯的多种类型更多相关视频
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