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中性细胞外细胞陷通过刺激骨质细胞形成来加剧上性牙周炎

João Luiz Guilherme Neto¹, Lucas Gabriel Rodrigues Venturini¹, Ayda Henriques Schneider²

¹Laboratory of Bone Biology, Department of BioMolecular Sciences, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil; Center for Research in Inflammatory Diseases, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil.

Journal of endodontics

|August 24, 2023

概括

中性细胞外细胞陷 (NETs) 导致骨质损失. 降低NETs降低了病变大小和骨质细胞活性,突出显示了它们在脉感染引起的骨复苏中的作用.

科学领域:

口腔生物学口腔生物学
免疫学免疫学免疫学
病理学病理学病理学

背景情况:

中性细胞外细胞陷 (NETs) 是参与杀死细菌的DNA和蛋白质结构.
牙周的牙周炎,通常是由真皮感染引起的,涉及显著的骨再吸收.

研究的目的:

在小鼠模型中研究NETs在与脉感染诱导的牙周炎相关的骨再吸收中的作用.

主要方法:

在小鼠中,通过暴露牙纸,诱导了牙上性牙周炎.
通过免疫光测定NET;用DNase I治疗小鼠以降低NET.
评估了上病变的大小,骨质细胞数量和骨质细胞分化标志物.

主要成果:

在小鼠和人类活检中,在病变部位确认了NET.
DNase I 治疗减少了 NETs,顶端病变大小和气泡骨再吸收.
这种减少与炎症和骨质细胞活性降低相关,包括关键基因表达.

结论:

NETs在脉感染后的牙周炎的局部炎症和骨再吸收特征中发挥着重要作用.
针对NETs可能提供一种治疗策略,用于管理这种疾病中的骨质损失.

关键词:

亚皮性牙周炎 (apical periodontitis) 是一种牙周炎.骨质再吸收骨质再吸收中性粒细胞外细胞陷中性粒细胞中性粒细胞.骨质细胞的骨质细胞.

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