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肠道微生物组和代谢组在花生过敏发展中的纵向动态

Yoojin Chun¹, Alexander Grishin², Rebecca Rose³

¹Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY.

The Journal of allergy and clinical immunology

|August 24, 2023

概括

婴儿肠道微生物群的多样性和特定的代谢物与花生过敏 (PA) 的发展有关. 肠道细菌和代谢物的变化随着时间的推移在患有PA的儿童中不同,为预防策略提供了见解.

科学领域:

微生物组研究的研究.
代谢学代谢学代谢学
过敏的发展过敏的发展.

背景情况:

越来越多的花生过敏 (PA) 需要了解它的发展.
微生物群及其代谢物影响食物过敏风险.

研究的目的:

研究与PA发展有关的肠道微生物组和代谢组动态.
确定预测PA的早期生活因素.

主要方法:

从多中心队列中对122名婴儿进行了纵向整合性研究.
使用16S rRNA测序和代谢组概况分析婴幼儿和中幼儿时期的便样本.
测量的短链脂肪酸.

主要成果:

28.7%的婴儿在童年中期就出现了PA.
较低的婴儿肠道微生物群多样性与PA发展相关 (P=.014).
在患有PA的儿童中观察到特定细菌 (例如,Clostridium,Bifidobacterium) 和代谢物 (例如,丁酸盐,异酸盐) 的明显时间变化.

结论:

儿童早期的临时肠道微生物组和代谢组动态在患有PA的儿童中不同.
这些发现有助于理解PA机制和潜在的预防策略.

关键词:

对于花生过敏的过敏食物过敏食物过敏在这里,我们可以看到子子.基因组胺组胺的使用方法这就是histidine.综合集成的整合.代谢组代谢组的代谢微生物组是一个微生物组.网络网络网络网络网络网络短链脂肪酸是一种短链脂肪酸.

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