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在脊髓损伤的受试者中,心脏高灵敏性T罗宁T血清度升高

Björn Wagner¹, Norbert Weidner¹, Andreas Hug¹

¹Spinal Cord Injury Center, Heidelberg University Hospital, Germany.

International journal of cardiology

|August 24, 2023

概括

在脊髓损伤 (SCI) 患者中,心脏中高水平的热素T (cTnT) 是常见的,但并不表明心脏受损. 临床医生应该考虑骨肌肉作为这些"假阳性"结果的来源.

科学领域:

生物化学生物化学
心脏病学心脏病学
神经学神经学

背景情况:

高灵敏性心脏托波宁 (hs-cTn) 是心肌损伤的已知生物标志物.
在肌肉病症中观察到独立于心脏事件的hs-cTn水平升高.
在脊髓损伤 (SCI) 中非心脏hs-cTn升高的发生程度尚不清楚.

研究的目的:

在SCI患者中确定非心脏hs-cTn在99百分位以上升高的频率.
为了比较心脏热血素T (cTnT) 和心脏热血素I (cTnI) 在SCI中的非心脏升高.

主要方法:

一个单一的,横截面研究,涉及30名没有心脏症状的SCI受试者.
血液样本被分析为hs-cTnT和hs-cTnI血清度.

主要成果:

60%的SCI受试者 (18/30) 显示hs-cTnT水平高于上限 (URL).
相比之下,没有SCI受试者根据各自的URL显示hs-cTnI水平升高.
三名hs-cTnT升高的受试者满足了基于6小时连续测试的急性心肌损伤标准,尽管缺乏心脏症状.

结论:

SCI患者经常呈现高hs-cTnT,但没有心肌损伤的证据.
临床医生应该意识到SCI中的潜在骨肌肉衍生的"假阳性"cTnT结果.
同时进行hs-cTnI分析可能有助于在SCI中增加cTnT水平时进行诊断澄清.

关键词:

生物标志物生物标志物脊髓损伤导致的脊髓损伤这种药物叫做托罗邦尼 (Troponin).

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