五甲基葡萄糖稳定脱细胞牛 jugular 静脉管道作为肺管道替换
Dipasha Sinha1, Agnes Nagy-Mehesz1, Dan Simionescu1
1Department of Bioengineering, College of Engineering, Computing and Applied Sciences, Clemson University, Clemson, South Carolina 29634, USA.
一种新的五甲基葡萄糖稳定脱细胞的门牛静脉管道 (PGG-DBJVC) 对儿科先天性心脏病患者显示出有前途. 这种生物相容的植入物抵抗化和降解,可能减少重复手术.
科学领域:
- 生物材料科学 生物材料科学
- 心血管外科心血管外科
- 再生医学是一种再生医学.
背景情况:
- 遗传性心脏病 (CHD) 每年影响美国约4万名新生儿.
- 每年有2500名心血管疾病患者需要进行管道动脉置换.
- 电流管道有其局限性:刚性,化,感染,血栓形成和缺乏生长.
研究的目的:
- 评估一种新型五甲基葡萄糖 (PGG) 的功能性和生物相容性,稳定脱细胞化膜牛 jugular 静脉管道 (PGG-DBJVC).
- 评估PGG-DBJVC作为患有心脏病的儿科患者本土动脉的潜在替代品.
主要方法:
- 与原生和甲基固定组织的机械性能比较.
- 酶降解耐受性测试 (原酶,弹性酶).
- 在大鼠中进行皮下植入,以评估生物相容性和化.
- 在绵羊中植入肺管以评估功能和宿主反应.
主要成果:
- PGG-DBJVC的机械性能与原生和固定组织相似.
- 组织表现出对原酶和弹性酶降解的抗性.
- 皮下植入物是生物相容的,并且耐化.
- 绵羊的肺部植入物显示出良好的功能,宿主细胞再生和最小的炎症.
结论:
- PGG-DBJVC是一种机械稳固,生物相容,耐降解的导体.
- 该设备显示出作为儿童心脏病患者有利的替代选择的潜力.
- 这种方法可以减少由于生长和与宿主组织的融合而需要重新操作的需要.
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