抗脂综合征中的血小板减少:抗凝和/或抗聚合总是需要吗?
Stephane Zuily1, Ricard Cervera2, Thomas Foret3
1CHRU-Nancy, Vascular Medicine Division, French Referral Center for Rare Systemic and Autoimmune Diseases, F-54000 Nancy, France; Université de Lorraine, INSERM, DCAC, F-54000 Nancy, France.
Autoimmunity reviews
|August 24, 2023
概括
血小板缺血是抗脂综合征 (APS) 的常见特征,增加了血块和妊娠并发症的风险. 本综述讨论了低血小板的APS患者的抗凝策略.
科学领域:
- 类风湿病学 类风湿病学
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 抗脂综合征 (APS) 是一种自身免疫性疾病,其特征是血块和/或怀孕问题,与抗脂抗体 (aPL) 相关.
- 血小板减少或血小板数量低是APS的常见发现,也是2023年ACR/EULAR分类中的一个标准.
- 在APS患者中血小板的低值意味着血栓事件,产科并发症和全因死亡率的风险增加了三倍.
研究的目的:
- 审查关于APS患者的抗凝血和抗血小板治疗的辩论.
- 总结了关于管理策略的第七届国际风湿病和自身免疫学争议大会 (CORA) 上提出的论点.
主要方法:
- 在CORA 2023大会上提出的讨论和论点的回顾.
- 在APS的背景下,综合关于管理血小板缺血的专家意见.
主要成果:
- 在APS患者中,血小板缺血是不良临床结果的显著预测因素.
- 关于对低血小板的APS患者进行抗凝固剂或抗血小板治疗的必要性和类型的持续辩论存在.
结论:
- 在APS中存在血小板缺血症,需要仔细考虑血小板风险分层.
- 需要进一步的讨论和证据,以建立最佳的治疗指南,用于抗凝/抗聚在APS患者与血小板缩.
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