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吸烟暴露引起的供体肺中的支气管相关淋巴组织不会阻止移植后的耐受性诱导

Yuriko Terada¹, Wenjun Li¹, Hailey M Shepherd¹

¹Department of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

|August 24, 2023

概括

捐赠者的吸烟史不会使肺移植结果恶化. 吸烟诱导的供体肺中的支气管相关淋巴组织 (BALT) 是适应性的,并且不会增加急性细胞排斥,这表明免疫调节的潜力.

科学领域:

免疫学免疫学免疫学
移植生物学移植生物学
呼吸系统医学呼吸系统医学

背景情况:

在供体肺部存在支气管相关的淋巴组织 (BALT) 假设加快移植后肺部移植的移植排斥.
长期暴露于烟雾会诱导BALT,但捐赠者吸烟对非免疫反应的影响尚不清楚.

研究的目的:

调查捐赠者的吸烟史对非免疫反应和肺移植结果的影响.
在移植肺部中描述吸烟引起的BALT的行为.

主要方法:

使用的小鼠模型的肺移植与供体肺展现吸烟诱导的BALT.
分析了BALT移植后的细胞组成 (Foxp3+ T细胞) 和动态重组.
在BALT.中检查了受体白细胞的招募和移植寄养供体细胞的替换.

主要成果:

供体肺中的吸烟诱导的BALT含有Foxp3+ T细胞,在移植后经历了显著的重组.
受体白细胞被招募到BALT中,并取代移植寄存的供体细胞.
在老鼠和人类数据中,捐赠者的吸烟史与急性细胞排斥增加或异位移植接受受损无关.

结论:

供体肺中的支气管相关淋巴组织 (BALT) 在移植后表现出可塑性.
捐赠者的吸烟史不会对肺移植结果产生负面影响,也不会促进急性排斥.
BALT的适应性可能为调节免疫反应提供途径,可能促进耐受性或控制炎症.

关键词:

提供者吸烟吸烟接种器的拒绝移植器的拒绝肺部移植肺部移植三级淋巴体器官的第三级淋巴体器官

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