脑血管炎作为肺炎球菌脑膜炎的并发症:一个队列研究
Agathe Artiaga1, Fanchon Herman2, Caroline Arquizan3
1Infectious and Tropical Diseases Department - University Hospital of Montpellier, France.
Infectious diseases now
|August 24, 2023
概括
大脑血管炎 (CV) 是肺炎球菌脑膜炎 (PM) 的常见并发症. 德甲没有预防心血管疾病,这与延迟护理和高炎症标志物有关.
科学领域:
- 神经学 神经学
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
背景情况:
- 大脑血管炎 (CV) 是肺炎球菌脑膜炎 (PM) 的严重并发症.
- 德克萨米他在预防PM患者心血管疾病方面的作用尚未得到充分证实.
研究的目的:
- 调查PM患者中CV的发生情况.
- 为了确定与心血管发育相关的因素,包括使用德甲.
主要方法:
- 成年PM患者 (2002-2020) 的回顾性,双中心观察性研究.
- 由神经系统恶化和相容成像定义的CV;由神经病学家裁决的病例.
- 多变量分析确定了与CV相关的因素,包括甲和CSF蛋白质水平.
主要成果:
- CV发生在29.2%的PM患者中,诊断后8天的中位数.
- 最初高的C-反应蛋白 (CRP) 和CSF蛋白水平与CV相关.
- 延迟入院和NSAID摄入显示了与CV的边际关联;德甲没有影响发生.
结论:
- CV是PM的常见和严重并发症.
- 延迟医疗护理,高CRP和高CSF蛋白水平与心血管发育有关.
- 德克萨米他的使用并没有降低该队列中心血管病发病率.
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