连接粘附分子样蛋白 (JAML) 对于接触过敏期间的炎症反应很重要
Veronika Mraz1, Rebecca K D Lohmann1, Mandy Menzel1,2
1The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, The University of Copenhagen, Copenhagen, Denmark.
连接粘附分子样蛋白 (JAML) 对于接触过敏反应至关重要. JAML淘汰赛小鼠显示炎症减少,表明JAML是过敏接触性皮肤炎 (ACD) 的潜在治疗标.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 细胞生物学 细胞生物学
背景情况:
- 结合粘附分子样蛋白 (JAML) 参与伤口愈合和T细胞激活.
- 它在接触过敏症 (CHS) 中的作用,这是过敏接触性皮肤炎 (ACD) 的一个模型,以前是未知的.
研究的目的:
- 调查JAML在CHS发展中的作用.
- 探索JAML在CHS期间T细胞反应中的功能.
主要方法:
- 在CHS研究中使用了JAML淘汰 (KO) 和野生型 (WT) 鼠标模型.
- 评估了JAML连接体,Coxsackievirus和腺病毒受体 (CXADR) 在体外和体内角质细胞上的表达.
主要成果:
- 在CHS的敏感化和诱导阶段,JAML KO小鼠表现出明显减少的炎症反应.
- 在JAML KO小鼠的表皮中观察到CD8+和CD4+T细胞的数量减少.
- 在JAML KO小鼠中,IFNγ,IL-1β和CXCL10等关键炎症媒介的产生下降.
- 鉴定出CD8+ T细胞表达JAML,这对于快速过敏爆发反应至关重要.
- 在暴露于接触过敏原时,角质细胞上调了CXADR.
结论:
- 在接触过敏症中,JAML发挥着核心作用.
- 在治疗人类过敏接触性皮肤炎方面,JAML是一个有前途的治疗标.
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