在精神分裂症中表面和深层白质的结构性损伤
Sung Woo Joo1, Young Tak Jo2, Soojin Ahn1
1Department of Psychiatry, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea.
Acta neuropsychiatrica
|August 24, 2023
概括
精神分裂症患者在深白质 (DWM) 和表面白质 (SWM) 两部分都表现出结构性大脑损伤. 表面白质 (SWM) 可能是未来精神分裂症生物标志物研究的关键领域.
科学领域:
- 神经成像是一种神经成像.
- 精神病学神经科学 精神病学神经科学
- 白物质研究 白物质研究
背景情况:
- 精神分裂症通常与大脑区域的脱节有关.
- 由于重建的挑战,在精神分裂症中,表面白质 (SWM) 的研究较深白质 (DWM) 较少.
研究的目的:
- 研究精神分裂症患者的深白质 (DWM) 和表面白质 (SWM) 区域的结构差异.
- 探索SWM作为精神分裂症神经生物标志物的目标的潜力.
主要方法:
- 利用来自223名健康对照组和143名精神分裂症患者的扩散磁共振成像 (dMRI) 数据.
- 进行了全脑双张力通道图和纤维聚类,比较不同组的分数异构性 (FA).
- 使用斯皮尔曼的rho和Bonferroni校正分析了FA偏差和临床症状之间的关联.
主要成果:
- 与对照组相比,精神分裂症患者在14个深白质 (DWM) 和4个表面白质 (SWM) 环节中表现出较低的微分异质 (FA).
- 这些FA差异的效果大小很小.
- 在皮质脊髓和表面尾道的FA偏差和负症状得分之间观察到负相关性,但在多次测试调整后并不显著.
结论:
- 在精神分裂症中,深白质 (DWM) 和表面白质 (SWM) 路径中存在结构性损伤.
- 表面白质 (SWM) 需要进一步调查,因为它是精神分裂症神经生物标志物的潜在目标.
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