在肝移植接受者中,COVID-19疫苗的临床应用
Feng-Chao Liu1, Man Xie2, Wei Rao1
1Division of Hepatology, Liver Disease Center, The Affiliated Hospital of Qingdao University, Qingdao 266000, China; Organ Transplantation Center, The Affiliated Hospital of Qingdao University, Qingdao 266000, China; Institute of Organ Donation and Transplantation of Qingdao University, Qingdao 266000, China.
Hepatobiliary & pancreatic diseases international : HBPD INT
|August 24, 2023
概括
在肝移植接受者 (LTRs) 中的COVID-19疫苗接种在初始剂量后显示出较低的抗体反应. 增强剂 (3rd或4th剂量) 提高免疫力,但一些LTRs仍然没有反应,并且可能发生诸如异种移植排斥等不良事件.
科学领域:
- 免疫学 免疫学 免疫学
- 移植科学 移植科学
- 传染性疾病 传染性疾病
背景情况:
- COVID-19大流行严重影响了固体器官移植 (SOT) 活动,特别是肝脏移植.
- 肝移植接受者 (LTRs) 免疫力低下,面临SARS-CoV-2感染和严重COVID-19结果的风险增加.
- 由于LTRs的脆弱性,强烈建议对LTRs进行早期的COVID-19疫苗接种.
研究的目的:
- 审查各种COVID-19疫苗剂量后LTRs中抗体反应的最新数据.
- 为了确定与低最佳血清反应相关的风险因素,LTRs.
- 总结LTR群体接种疫苗后报告的不良事件.
主要方法:
- 使用PubMed.com进行了文献搜索.
- 关键词包括"肝移植"",SARS-CoV-2"和"疫苗",以确定相关研究.
- 该审查综合了关于LTRs疫苗有效性和安全性的研究结果.
主要成果:
- 最初的疫苗剂量 (第1次和第2次) 在LTRs中引起了较差的抗体反应.
- 第三或第四剂疫苗显著改善了免疫反应和抗体标位.
- 尽管有助剂,但LTRs的一个子集显示出缺乏血清反应,一些经历了不良事件,包括异种移植排斥和肝损伤.
结论:
- 需要多个疫苗剂量来增强LTRs中的抗体反应.
- 疫苗反应不良和潜在不良事件的危险因素需要进一步调查.
- 该审查强调了COVID-19大流行期间肝移植接受者的疫苗接种,免疫力和安全性之间的复杂相互作用.
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