在亚洲患者中患有非酒精性脂肪肝疾病的功能损失的患病率和危险因素
Chao Sun1, George Boon-Bee Goh2, Wan-Cheng Chow2
1Center for Fatty Liver Disease, Department of Gastroenterology, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Key Lab of Pediatric Gastroenterology and Nutrition, Shanghai 200092, China.
Hepatobiliary & pancreatic diseases international : HBPD INT
|August 24, 2023
概括
非酒精性脂肪肝 (NAFLD) 与脏问题有关. 晚期肝纤维化和高血糖是NAFLD患者功能障碍的关键危险因素.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 腎臟病學 (nephrology) 是一種醫學.
- 代谢综合征是代谢综合征的一种.
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 经常与功能受损和其他代谢障碍有关.
- 在NAFLD患者中,功能障碍的患病率和特定风险因素需要进一步阐明.
研究的目的:
- 为了确定NAFLD患者功能障碍的患病率.
- 在这个人群中确定与功能障碍相关的独立风险因素.
主要方法:
- 在8个亚洲中心对529名成年人 (18-70岁) 进行了前性研究,他们通过超声波诊断出NAFLD.
- 使用FibroScan-aspartate aminotransferase (FAST),Agile 3+和Agile 4分数进行评估的肝纤维化和肝硬化.
- 通过使用CKD-EPI方程估计的膜过率 (eGFR) 评估功能,定义功能受损 (<90mL/min/1.73m2) 和慢性病 (CKD) (<60mL/min/1.73m2).
主要成果:
- 在NAFLD患者中,功能障碍和CKD的患病率分别为37.4%和4.9%.
- 晚期肝纤维化/肝硬化 (敏捷3+/敏捷4分) 独立预测CKD.
- 升高的禁食血葡萄糖 (FPG) 和血压显著与功能受损有关,即使在调整代谢综合征成分后也是如此.
- 与正常血糖相比,糖尿病前期 (FPG ≥5.6 mmol/L或HbA1c ≥5.7%) 增加了功能受损的可能性.
结论:
- 敏捷3+和敏捷4分数有效地识别了高风险患CKD的NAFLD患者.
- 在糖尿病前期早期的血糖控制可能对NAFLD患者的功能产生保护作用.
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