抗体介导的NK细胞激活作为抗流感感染免疫的相关因子
Carolyn M Boudreau1,2, John S Burke1, Ashraf S Yousif1
1Ragon Institute of MGH, MIT, and Harvard, Cambridge, MA, 02129, USA.
Nature communications
|August 24, 2023
概括
激活自然杀手 (NK) 细胞的抗体对于老年人流感保护至关重要. 目前的疫苗无法诱导足够的NK细胞激活抗体,需要下一代疫苗.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- 老年学是一门学科.
背景情况:
- 抗体对流感免疫力至关重要,但标位和中和是不够的关联.
- 参与天生的免疫系统的抗体效应因子功能对于保护和病毒清除至关重要.
- 老年人表现出免疫性,影响疫苗反应和易受感染的可能性.
研究的目的:
- 在老年人中全面描述对流感疫苗接种的幽默免疫反应.
- 调查抗体效应因子功能在预防流感感染中的作用.
- 在老年人中确定下一代流感疫苗的潜在目标.
主要方法:
- 在接种疫苗的老年人 (65岁以上) 中对幽默性免疫反应进行后期分析.
- 在2012/2013季节对流感感染的监测.
- 对流感特异性抗体效应因子功能的分析,包括NK细胞激活.
主要成果:
- 接种疫苗的老年人产生了强大的抗体反应,但感染者和未感染者之间的效应特征不同.
- 被感染的个体缺乏针对血凝素和神经氨基酶的NK细胞激活抗体.
- NK细胞激活与衰老标记CD57相关,表明老年人NK细胞功能受损.
结论:
- 流感特异性NK细胞激活抗体对于老年人的保护至关重要.
- 目前的高剂量流感疫苗不足以诱导保护性NK细胞激活性幽默反应.
- 需要下一代疫苗选择性诱导afucosylated,NK细胞激活抗体,以增强老年人群的流感保护.
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