在冠状动脉中使用基乙醇粉进行非对比光学连贯性断层成像的可行性和安全性
Dong Oh Kang1,2, Hyeong Soo Nam3, Sunwon Kim1,4
1Multimodal Imaging and Theranostic Laboratory, Cardiovascular Center, Korea University Guro Hospital, 148 Gurodong-Ro, Guro-Gu, Seoul, 08308, Republic of Korea.
Scientific reports
|August 24, 2023
概括
粉是一种替代性冲洗剂,可提供安全有效的非对比光学连贯性断层扫描 (OCT) 成像. 这种方法可确保出色的图像质量,使其成为功能障碍患者的可行选择.
科学领域:
- 心血管成像 - 心血管成像
- 医疗器械技术 医疗器械技术
背景情况:
- 冠内光学相干断层扫描 (OCT) 需要冲洗介质来获取图像.
- 对比介质可以增加对比引起的功能障碍的风险,需要替代解决方案.
研究的目的:
- 调查使用粉 (基乙粉) 作为临床OCT成像中的冲洗剂的可行性和安全性.
- 为了比较对比介质和粉冲洗之间的图像质量和形态测量.
主要方法:
- 预计将招募43名患有70个冠状动脉病变的患者.
- 通过手动注射对比剂,然后用粉粉,获得81个OCT回撤对.
- 使用自动化的光线轮/支架支架细分算法进行框架对框架的评估.
- 清晰图像段 (CIS),血液冲洗能力和对照图像之间的定量形态测量测量的比较.
主要成果:
- 在对比度和粉冲洗之间可比的整体图像质量 (97.1%对比96.5%CIS,p=0.160).
- 两组之间的血液冲洗能力相似 (p=0.125).
- 具有良好的相互关联的定量形态测量结果,具有很好的测量间变性 (p<0.001).
- 在接受粉OCT成像的患者中没有观察到临床相关的并发症或脏恶化.
结论:
- 使用粉进行非对比性OCT成像是临床上安全且技术上可行的.
- 粉提供优良的图像质量,为患有功能障碍的高风险患者提供有前途的替代方案.
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