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通过HECT E3 UBR5通过K48连接的乌比奎链形成的结构快照

Laura A Hehl1,2, Daniel Horn-Ghetko2, J Rajan Prabu2

  • 1Department of Chemistry, School of Natural Sciences, Technical University of Munich, Garching, Germany.

Nature chemical biology
|August 24, 2023
PubMed
概括

研究人员可视化了UBR5是HECT家族E3结合酶,如何构建K48链接的泛素链. 这揭示了泛素链形成的结构机制,这对于细胞调节至关重要.

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