内部神经元亚型在控制新皮质试验对试验输出变化的作用
Lihao Guo1,2, Arvind Kumar3,4
1Division of Computational Science and Technology, School of Electrical Engineering and Computer Science, KTH Royal Institute of Technology Stockholm, Stockholm, Sweden. lihaog@kth.se.
Communications biology
|August 24, 2023
概括
神经元活动的变化是由输入平衡和共变量所塑造的,而不仅仅是网络结构. 这项研究揭示了不同的内部神经元类型如何控制皮质电路中的试验逐试验变化.
科学领域:
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
- 皮层电路动力学 皮层电路动力学
背景情况:
- 神经元活动的试验对试验的变化是影响活体刺激反应的基本属性.
- 以前的计算模型专注于本地网络结构和前输入来解释这种变化.
- 输入统计和各种内部神经元亚型对神经元变异性的影响仍然不太清楚.
研究的目的:
- 调查输入统计数据和内部神经元亚型如何影响刺激反应动态.
- 探索不同抑制性内部神经元群体 (PV,SST,VIP) 在逐个试验中塑造变异性的作用.
主要方法:
- 皮层微电路模型的开发和分析.
- 包括一个激发性和三个不同的抑制性内部神经元群体 (帕尔瓦尔胺,索马托斯塔丁,血管活性肠).
- 检查输入平衡和协差对网络输出变量的影响.
主要成果:
- 对神经元群的输入和输入共差的平衡被确定为输出试验对试验变化的主要驱动因素.
- 输入协差的影响取决于输入的平衡.
- 皮质网络在帕瓦胺 (PV) 主导状态下显示出减少的输出变异性,相比于索马托斯塔丁 (SST) 主导状态.
结论:
- 输入统计数据和内部神经元亚型批判性地调节神经元试验对试验的变化.
- 阐明了对输出变量的上下文,状态和任务依赖控制的机制.
- 这些发现凸显了抑制性内部神经元多样性在调节皮质电路功能的重要性.
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