他的角度作为反流机制的可测量元素
Samer Michael1,2, Gad Marom3,4, Ronit Brodie3
1Department of General Surgery, Hadassah-Hebrew University Medical Center, POB 12000, 91120, Jerusalem, Israel. samer.s.michael@gmail.com.
概括
对于GERD的基底复合手术创造了His的急角,减少了食道胃孔区域,并防止了反流. 这项研究通过将His的角度和孔径大小与反流发生相关联来澄清反流机制.
科学领域:
- 胃肠病学 胃肠病学
- 手术创新 在外科创新.
- 医疗器械开发 医疗器械开发
背景情况:
- 胃食道逆流性疾病 (GERD) 是一种普遍的疾病,源于抗逆流障碍的损害.
- laparoscopic fundoplication 是GERD的首选手术治疗方法,但其精确的抗反流机制仍在争论中.
- 了解这些机制对于优化GERD治疗策略至关重要.
研究的目的:
- 为了研究胃食道逆流,基底复合技术和他的角度之间的关系.
- 阐明生物力学因素,这些因素有助于基底复合在预防反流的有效性.
- 建立一个可重现的实验模型来评估反反流机制.
主要方法:
- 利用一个实验模型用扩展的猪胃,分为控制,骨髓切割,尼森基底复合和图佩特基底复合组.
- 采用一个可倾斜的平台来模拟食道 - 胃结处的水静压.
- 通过光镜测量了His的角度,通过内镜测量了食道胃孔区域,记录了反流的发生.
主要成果:
- 他的角度更大,孔面积更大与对照组和肌肉切割组的反流增加有显著的相关性.
- 基因组复合 (尼森和图佩) 显著降低了反流的发生,反流很少超过-30°的倾斜.
- 尼森和图佩特的基底应用在预防反流方面表现出相似的有效性.
结论:
- 他的角度是抗反流机制的可测量组成部分,直接影响食道胃孔区域.
- 基部复合有效地缩小了His的角度,并减少了孔径面积,从而减少了反流的发生率.
- 这项研究提供了实验证据,支持基因组复制在治疗GERD方面的成功的生物力学基础.
相关概念视频
01:17Bernoulli's Principle: Applications
3.9K
There are many devices and situations in which fluid flows at a constant height and so can be analyzed using Bernoulli's principle. These devices include, but are not limited to, entrainment devices and fluid flow measuring devices.
Entrainment devices use a high fluid speed to create low pressures and, thus, entrain one fluid into another. Some examples of these devices are given below:
Entrainment devices use a high fluid speed to create low pressures and, thus, entrain one fluid into another. Some examples of these devices are given below:
3.9K
01:14Node Analysis for AC Circuits
349
Consider an angioplasty system featuring a catheter equipped with a turbine, a critical tool for removing plaque deposits from coronary arteries. This intricate medical device operates using a circuit model reminiscent of a dual-node RLC circuit powered by a current-controlled voltage source.
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
To unravel the complexities of this system, nodal analysis is employed, a powerful technique founded on Kirchhoff's current law (KCL), which remains valid for phasors. AC circuits can effectively be...
349
01:15Unsymmetric Bending - Angle of Neutral Axis
347
Unsymmetrical bending occurs when a structural member is subjected to bending moments in a plane that does not align with the member's principal axes. This scenario typically arises in beams and other structural components when loads are applied at non-ideal angles, introducing complexities in stress analysis.
When a bending moment is applied at an angle θ concerning the vertical axis of a symmetrical member, it can be resolved into components along the member's principal...
When a bending moment is applied at an angle θ concerning the vertical axis of a symmetrical member, it can be resolved into components along the member's principal...
347
01:13Contact Angle
12.4K
When a solid is dipped inside a liquid, the liquid surface becomes curved near the contact. For some solid–liquid interfaces, the liquid is pulled up along the solid, while for others, the liquid surface is convex or depressed near the solid surface. This phenomenon can be explained using the concept of cohesive and adhesive forces.
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
The adhesive force is the molecular force between molecules of different materials, that is, between the molecules of the solid and the liquid. The cohesive...
12.4K
01:10Relative Motion Analysis - Acceleration
378
A slider-crank mechanism converts rotational motion from the crank into linear motion of the slider or vice versa. This mechanism consists of three main parts: the crank, the connecting rod, and the slider. The movement of the slider-crank is an example of general plane motion as the fluctuating angle between the crank and the connecting rod. Consider a segment AB where point A is at the end of the slider and point B is on the diametrically opposite end to point A, on a crack. The variance in...
378
01:32Radical Anti-Markovnikov Addition to Alkenes: Thermodynamics
1.9K
The anti-Markovnikov addition of hydrogen halides to an alkene is thermodynamically feasible only with HBr. The radical addition reaction with other hydrogen halides like HCl and HI is thermodynamically unfavorable.
1.9K