血囊/甲因比率与心脏病患者的左心室透静功能有关
Junko Asakura1, Manabu Nagao2, Masakazu Shinohara3,4
1Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine, Kobe, Japan.
Heart and vessels
|August 24, 2023
概括
高水平的同类氨酸 (Hcy) 与心血管疾病有关. 这项研究发现,高氨酸/甲氨酸 (CySS/Met) 比率与心脏病患者的腹功能障碍有关,独立于其他危险因素.
科学领域:
- 心脏病学 心脏病学
- 代谢学 代谢学 代谢学
- 生物化学 生物化学
背景情况:
- 循环homocysteine (Hcy) 的升高是一个已知的心血管疾病 (CVD) 风险因素.
- 对于Hcy代谢物和左心室 (LV) 透静功能之间的关系还不清楚.
- 扩张性功能障碍 (DD) 是心脏病 (HD) 的关键组成部分.
研究的目的:
- 研究心脏病患者血Hcy相关代谢物与腹功能障碍 (DD) 之间的关联.
- 为了确定特定的Hcy代谢物是否独立地与LV的扩张功能标记物相关.
主要方法:
- 分析了62名患有维护LV喷射分数 (LVEF ≥50%) 的HD患者.
- 血Hcy及其衍生物使用液态染色法-质谱法 (LC-MS/MS) 来量化.
- 使用斯皮尔曼相关性和多重线性回归模型来评估代谢物-透气功能关系.
主要成果:
- 囊/甲因 (CySS/Met) 比率与 LV 透静功能 (E/e'比率) 显示出显著的正相关性.
- 具有较高E/e'值的患者表现出显著更高的血CySS/Met比率.
- 在调整了多个临床混因素后,CySS/Met比率与E/e'独立相关.
结论:
- 在心脏病患者中,高的血CySS/Met比率表明了心脏病患者的透气功能障碍.
- 该CySS/Met比率可以作为一个潜在的生物标志物来评估HD的透缩功能.
- 需要进一步的研究来探索CySS/Met比率与DD之间的机制联系.
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