GMMAD:人类肠道微生物代谢物与疾病相关的综合数据库
Cheng-Yu Wang1,2, Xia Kuang2, Qiao-Qiao Wang2
1Department of Respiratory and Critical Care Medicine, Zhongnan Hospital of Wuhan University, Wuhan, China.
BMC genomics
|August 24, 2023
概括
肠道微生物代谢物显著影响疾病. 肠道微生物代谢物与疾病协会 (GMMAD) 数据库链接疾病,微生物和代谢物,有助于发现疾病机制和潜在的候选药物.
科学领域:
- 微生物学 微生物学
- 代谢学 代谢学 代谢学
- 计算生物学 计算生物学
背景情况:
- 肠道微生物代谢物是影响人类疾病的关键因素.
- 了解疾病,微生物和代谢物之间的复杂相互作用对于开发向疗法和生物标志物至关重要.
研究的目的:
- 介绍肠道微生物代谢物与疾病协会 (GMMAD) 数据库,一个手动策划的资源.
- 为探索人类疾病,肠道微生物及其代谢物之间的关联提供一个全面的平台.
主要方法:
- 手动策划文献和现有资源,以建立数据库.
- 发展协会力量和信心评分的发展.
- 使用精选数据预测疾病代谢物相关性.
主要成果:
- 最初发布的GMMAD包括3,836种疾病微生物和879,263种微生物代谢物协会.
- GMMAD预测了220,690种疾病代谢物相关性.
- 一个用户友好的Web界面允许浏览,搜索和下载数据.
结论:
- GMMAD 作为一种独特的,免费可用的在线资源,用于肠道微生物代谢物与疾病的关联.
- 该数据库促进了对疾病机制的研究,以及对潜在药物和标记物候选物的识别.
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