在心房动中是一种心律失常的代谢物
Julia Krause1,2, Alexander Nickel3, Alexandra Madsen2,4
1University Center of Cardiovascular Science, Department of Cardiology, University Heart and Vascular Center Hamburg, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246, Hamburg, Germany.
Journal of translational medicine
|August 24, 2023
概括
长链乙 - 卡尼丁,特别是C18: 1AC,可以引发心律失常. 这种代谢物的高水平与心房动 (AF) 和心脏功能受损有关,这表明它是AF风险的潜在生物标志物.
科学领域:
- 心血管研究研究心血管研究
- 代谢学 代谢学 代谢学
- 系统医学 系统医学
背景情况:
- 长链乙碳酸 (ACs) 被认为是潜在的失常性代谢产物.
- 在心房动 (AF) 中C18:1AC的具体作用需要进一步阐明.
研究的目的:
- 通过系统医学方法研究C18:1AC对AF的贡献.
- 分析C18:1AC对心脏电生理学和新陈代谢的体外影响.
- 将体外发现转化为人类临床环境.
主要方法:
- 人类诱导多能干细胞 (iPSC) 衍生的工程心脏组织暴露于C18:1AC.
- 对收缩力,Ca2+处理和自发收缩的评估.
- 从AF患者的人类心房样本中分析C18:1AC对线粒体呼吸的影响.
- 血清C18:1AC度与AF发病率和流行率在基于人群和患者队列中的相关性.
主要成果:
- 短暂的C18:1AC暴露增强了收缩力,但引起了自发收缩和Ca2+处理受损.
- 连续C18:1AC暴露会损害收缩力.
- 在AF个体的心房线粒体中,C18:1AC抑制了呼吸.
- 血清C18:1AC水平升高与AF发病率和患病率的增加有关.
结论:
- C18:1AC通过干扰线粒体新陈代谢,显示出心律失常的潜力.
- C18:1AC有助于心脏收缩功能障碍.
- C18:1AC显示出作为AF风险的新型循环生物标志物的潜力.
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