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Updated: Jul 18, 2025

A Kinetic Fluorescence-based Ca2+ Mobilization Assay to Identify G Protein-coupled Receptor Agonists, Antagonists, and Allosteric Modulators
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使用 Gα12/13 G 蛋白质嵌合体重定向 GPR56 信号

Felix Faas1, Amalie Nørskov2, Peter J Holst1,3

  • 1Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.

Basic & clinical pharmacology & toxicology
|August 25, 2023
PubMed
概括

研究人员开发了新的仿制G蛋白来检测粘附G蛋白结合受体 (aGPCRs) 的信号,特别是GPR56,克服了研究这些重要药物标的挑战.

关键词:
G 蛋白质的奇默体.与G蛋白结合的7TM受体第二种类型:粘附性GPCRs.药物的发现和开发.结果措施的结果措施.

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