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Updated: Jun 18, 2026

Photo-Induced Cross-Linking of Unmodified Proteins PICUP Applied to Amyloidogenic Peptides
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Photo-Induced Cross-Linking of Unmodified Proteins PICUP Applied to Amyloidogenic Peptides

Published on: January 12, 2009

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未经修改的α-Synuclein Oligomers的光诱导交叉链接

Lei Ortigosa-Pascual1, Thom Leiding1, Sara Linse1

  • 1Department of Biochemistry and Structural Biology, Lund University, 221 00 Lund, Sweden.

ACS chemical neuroscience
|August 25, 2023
PubMed
概括

未经修改的蛋白质的光诱导交叉链接 (PICUP) 被优化为研究蛋白质寡合体. 改进的方法显示,较小的粉样蛋白寡合体更缩,直接从单体中形成.

关键词:
帕金森病是帕金森氏症的一种疾病.交叉链接是指交叉链接.组织组织组织组织组织组织.自动组装的自动组装机结构 结构 结构 结构

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Amyloid Fibrils03:03

Amyloid Fibrils

Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining, normally used to...