HER2阳性乳腺癌:共同向克服治疗耐药性
Paola Zagami1,2,3, Luca Boscolo Bielo1,2, Eleonora Nicolò1,2,4
1Division of Early Drug Development for Innovative Therapies, European Institute of Oncology IRCCS.
Current opinion in oncology
|August 25, 2023
概括
与其他途径对HER2 (人体表皮生长因子受体2) 的共同向可以克服HER2阳性乳腺癌的抗性. 这一战略有望改善这种异质性疾病患者的治疗结果.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗HER2 (人类表皮生长因子受体2) 药物显著改善了HER2阳性乳腺癌的结果.
- 然而,初级和二级耐药性限制了患者子组的治疗疗效.
- 了解HER2+乳腺癌异质性对于开发新的治疗策略至关重要.
研究的目的:
- 审查目前关于与其他信号通路共同向HER2的数据,以克服对抗HER2疗法的耐药性.
- 探索 HER2 阳性乳腺癌的新疗法组合.
主要方法:
- 对研究对HER2-阳性乳腺癌的共同向策略的文献综述.
- 对新型预测生物标志物和治疗点的数据分析.
- 综合了涉及HER2与激素受体,PI3K通路,其他HERS受体和免疫检查点的组合发现.
主要成果:
- 新的预测生物标志物正在出现,以指导对抗HER2治疗的反应.
- 与激素受体共同向HER2是对HER2+/HR+乳腺癌的验证方法.
- 针对HER2与PI3K通路,其他HER受体或免疫检查点的组合显示出有希望的结果.
结论:
- HER2阳性乳腺癌是一种异质性疾病,需要量身定制的治疗方法.
- 将HER2与补充信号通路的共同向可以提高治疗效率并克服耐药性.
- 对新的点和组合进行持续的研究对于推进治疗方案至关重要.
更多相关视频
14:20Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
16.8K
13:19Quantifying Antibody-Dependent Cellular Cytotoxicity in a Tumor Spheroid Model: Application for Drug Discovery
Published on: April 26, 2024
2.7K
相关概念视频
02:57Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K
01:27Tumor Immunotherapy
556
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
556
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:38Mitogens and the Cell Cycle
6.6K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
6.6K
02:49Cancer Therapies
7.7K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.7K