在加纳的2型糖尿病患者中甲状腺功能障碍和血糖控制:一个比较的横截面研究
Samuel Asamoah Sakyi1, Bright Ameyaw1,2, Edwin Ferguson Laing1
1Department of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
Endocrinology, diabetes & metabolism
|August 25, 2023
概括
甲状腺功能障碍在加纳的2型糖尿病 (T2DM) 患者中很普遍,随着高血糖的增加而增加. 降低甲状腺刺激激素 (TSH) 和T3水平与较差的血糖控制有关,这表明在T2DM管理中需要对甲状腺进行监测.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 糖尿病研究 糖尿病研究
背景情况:
- 甲状腺疾病和糖尿病是成年人常见的内分泌疾病.
- 甲状腺功能障碍会破坏新陈代谢平衡,导致β细胞亡和葡萄糖耐受性受损.
- 关于甲状腺功能障碍对2型糖尿病患者血糖控制的具体影响的数据有限.
研究的目的:
- 调查甲状腺功能障碍和甘血控制在加纳T2DM患者之间的关系.
- 为了确定T2DM患者中甲状腺疾病的患病率.
- 为了确定与高血糖相关的特定甲状腺激素水平.
主要方法:
- 一项涉及192名T2DM患者的比较横截面研究.
- 对连续三个月的空腹血葡萄糖 (FBG) 和糖化血红蛋白 (HbA1c) 水平的分析.
- 测量甲状腺刺激激素 (TSH),自由三甲状腺素 (FT3),自由甲状腺素 (FT4) 和体重指数 (BMI).
主要成果:
- 甲状腺疾病的总体患病率为7.8%,严重高血糖症患者 (11.7%) 的患病率更高.
- 较低的血清TSH和FT3/FT4比率在严重高血糖症患者中观察到,与中度高血糖症和良好的血糖控制患者相比.
- 较低的TSH和FT3水平独立地与高糖血的几率增加有关.
结论:
- 甲状腺功能障碍在T2DM患者中很常见,其患病率随着高血糖症的严重程度而增加.
- 降低TSH和T3水平可能导致血糖控制恶化.
- 应将常规的甲状腺功能监测纳入加纳T2DM患者的管理.
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