[,维生素D,以及结肠直肠癌]
1Department of Internal Medicine, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
概括
维生素D和在降低结肠直肠癌风险方面表现有前途,但需要进行大规模试验来确认益处. 进一步的研究将澄清这些补充剂对结肠癌预防的影响.
科学领域:
- 在瘤学瘤学.
- 营养科学 营养科学
- 预防医学 预防医学
背景情况:
- 结肠直肠癌是一个重大的全球健康负担,受到生活方式和饮食因素的影响.
- 观察性研究表明,维生素D和可能会降低结肠直肠癌的风险,提高生存率.
- 现有的证据在很大程度上是观察性的,缺乏大规模的随机对照试验 (RCT) 来得出明确的结论.
研究的目的:
- 评估维生素D和在预防结直肠癌中的潜在作用.
- 突出需要进行强大的临床试验来研究这些微量营养素.
- 综合目前对维生素D和对结直肠癌的影响的理解.
主要方法:
- 对血清维生素D水平和结直肠癌风险的观察性研究的综述.
- 对研究摄入量及其与结直肠癌发病率和存活率的关系的分析.
- 鉴定干预研究,注意到对结肠癌的维生素D和研究的局限性.
主要成果:
- 观察数据表明,较高的维生素D水平与降低结直肠癌风险和更好的生存率相关.
- 在观察性研究中,摄入与降低结直肠癌发病率和改善生存率有关.
- 干预研究支持在预防结肠直肠腺瘤中的作用,但对维生素D和在结肠癌中结合的证据有限.
结论:
- 虽然观察数据令人鼓舞,但大规模随机对照试验对于确定维生素D和补充剂对结直肠癌的疗效至关重要.
- 需要进一步进行精心设计的干预研究,以阐明维生素D,和结肠癌之间的确切关系.
- 未来的研究应该专注于大规模的RCT,以提供关于维生素D和对结直肠癌结果的影响的明确证据.
相关概念视频
01:25Role of Vitamins in Maintaining Bone Health
3.4K
The growth and maintenance of bone are regulated by a combination of nutritional factors, including vitamins, such as vitamin A, B12, C, D, and K.
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
Vitamin A
Vitamin A is involved in the process of bone remodeling. Retinoic acid, the active metabolite of Vitamin A, has nuclear receptors in osteoblasts and osteoclasts, which are involved in bone remodeling.
Vitamin B12
Vitamin B12 acts as a cofactor during the formation of osteoblast-related proteins, such as osteocalcin. Vitamin B12 plays a role...
3.4K
01:21Skeleton and Calcium Homeostasis
4.6K
Calcium is not only the most abundant mineral in bone but also the most abundant mineral in the human body. Calcium ions are needed for bone mineralization, tooth health, heart rate regulation and strength of contraction, blood coagulation, the contraction of smooth and skeletal muscle cells, and the regulation of nerve impulse conduction. The average calcium level in the blood is about 10 mg/dL. When the body cannot maintain this level, a person will experience hypo or hypercalcemia.
4.6K
01:23Role of Skin in Vitamin D Synthesis
5.3K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
5.3K
01:17Hormones and Bone Tissue
2.7K
The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
2.7K
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:22Connective Tissue Cell Types
3.3K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.3K