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Updated: Jul 18, 2025

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口腔 Porphyromonas gingivalis 感染会影响肠道微生物群并促进动脉样硬化

Sowon Park¹, Inyoung Kim², Soo Jung Han³

¹Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, South Korea.

Journal of clinical periodontology

|August 25, 2023

概括

口腔感染 Porphyromonas gingivalis (PG) 会加剧动脉样硬化并改变肠道微生物群. 这项研究强调了牙周炎诱导的肠道失调如何可能导致动脉样硬化的发展.

科学领域:

微生物学微生物学
心血管疾病心血管疾病
胃肠病学胃肠病学

背景情况:

牙周炎和肠道失生症与动脉样硬化有关.
口腔病原体和动脉样硬化中的肠道微生物群之间的确切关系尚不清楚.

研究的目的:

研究口腔感染Porphyromonas gingivalis (PG) 对肠道微生物群组成和动脉样硬化进展的影响.
阐明牙周炎诱导的肠道失生症在动脉样硬化发展中的作用.

主要方法:

ApoE-/-小鼠接受了正常的,西方饮食或口腔PG感染的西方饮食.
分析了动脉样硬化病变,血清脂蛋白,肝脂代谢基因表达和便微生物群组成 (16S rRNA测序).

主要成果:

与西方饮食组相比,口服PG感染显著增加了大动脉动脉样硬化病变的1.7倍.
PG感染降低了高密度脂蛋白 (HDL) 和甘油三水平,降低了肝脏清洁剂受体B类型1 (SR-B1) 的表达,并改变了肠道微生物群的多样性和组成.
特定的细菌类 (Actinobacteria,Deferribacteres) 和物种 (Mucispirillum schaedleri,Lactobacillus gasseri) 的增加,以及与碳水化合物代谢相关的蛋白质的变化.

结论:

口服PG感染促进动脉样硬化,并诱导显著的代谢障碍,包括降低的HDL和改变的肝脂代谢.
肠道失生症伴随着牙周炎,可能在动脉样硬化的发病过程中发挥关键作用.

关键词:

葡萄牙牙牙病 Porphyromonas gingivalis 这种虫子是动脉样硬化动脉样硬化肠道失生症是指肠道失生症.我们的微生物群.

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