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Updated: Jul 18, 2025

Assessing Cellular Target Engagement by SHP2 PTPN11 Phosphatase Inhibitors
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Published on: July 17, 2020

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通过弹性网络模型和神经关系推断分子动力学模拟神经关系推断SHP2的全质激活机制的研究

Ling Liu1,2, Yan Cheng3, Zhigang Zhang2

  • 1Department of Thoracic Oncology, Affiliated Cancer Hospital, Guizhou Medical University, Guiyang, China. ouyangww73@163.com.

Physical chemistry chemical physics : PCCP
|August 25, 2023
PubMed
概括

这项研究揭示了SHP2酸酶在癌症免疫逃生中的全性机制. 了解这种SHP2通路有助于设计新的癌症抑制剂,用于与PD-1抗体结合治疗.

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