在斑块性牛皮症中,成功的secukinumab治疗与肠道微生物群的改变和相关的功能变化有关
Xueshan Du1, Cong Yan1, Shuzhen Kong1
1Department of Dermatology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Frontiers in microbiology
|August 25, 2023
概括
对牛皮的成功sequinumab治疗改变了肠道微生物群,增加了Firmicutes和Ruminococcaceae,同时减少了Bacteroidota. 这表明肠道微生物组具有更稳定的功能变化,可能有助于预测治疗疗效.
科学领域:
- 微生物组研究的研究.
- 免疫皮肤学 免疫皮肤学
- 药物基因组学 药物基因组学
背景情况:
- 牛皮的发病因子与肠道微生物组失调有关.
- 一种IL-17抑制剂Secukinumab在牛皮治疗中显示出有效性.
- 塞库金纽马布对肠道微生物群的影响在很大程度上仍未知.
研究的目的:
- 在成功治疗sequukinumab后,调查牛皮患者的肠道微生物群变化.
- 为了描述治疗后肠道微生物群的功能变化.
- 探索肠道微生物群和secukinumab疗效之间的关系.
主要方法:
- 16S rRNA测序以描述便微生物组.
- 对细菌群落和功能进行枪支元基因组测序.
- 治疗 (AT),未治疗 (BT) 牛皮患者和健康对照 (H) 之间的比较.
主要成果:
- 塞库金纽马布治疗显著改变了微生物的多样性和结构.
- 在AT组中观察到Firmicutes和Ruminococcaceae的增加,与减少的Bacteroidota (升高的F/B比率) 相比.
- 功能分析显示了KEGG通路的改变,包括下调的心血管疾病和上调的传染病,表明改善了肠道平衡.
结论:
- 在牛皮患者中,secukinumab疗法会诱导显著的肠道微生物群和功能转移.
- 肠道微生物组分析可能有助于预测secukinumab的疗效和潜在风险.
- 对银病的微生物组向疗法的进一步研究是有必要的.
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