糖尿病神经病变导致中等大小的外周动脉血管功能障碍
Fahrettin Ege1, Ömer Kazci2, Sonay Aydin3
1Department of Neurology, VM Medicalpark Hospital, Ankara 063200, Turkey.
World journal of clinical cases
|August 25, 2023
概括
糖尿病神经病变会损害手臂动脉中的交感血管收缩,与健康人群不同,他们表现出正常的血管收窄. 这表明糖尿病神经病变患者的血管运动功能障碍显著.
科学领域:
- 心血管生理学心血管生理学
- 神经学 神经学
- 糖尿病学 糖尿病学
背景情况:
- 交感神经系统通过血管收缩调节外周动脉直径,影响血液流动.
- 血管壁中的光滑肌肉细胞收缩缩了动脉,减少了血液流动.
- 了解血管运动反应对于评估糖尿病神经病变等疾病中的血管健康至关重要.
研究的目的:
- 为了比较健康受试者和患有疼痛性糖尿病神经病变的患者手臂动脉中的同情性血管运动反应.
- 为了确定糖尿病神经病变是否与中型动脉的血管运动功能障碍有关.
主要方法:
- 招募了41名糖尿病神经病变患者和41名健康对照.
- 在通过中枢神经电刺激进行同情刺激之前和之后,测量了手臂动脉直径和血流.
- 通过使用10 mA,1 Hz电刺激在5秒内诱导交感血管运动激活.
主要成果:
- 健康对照组在刺激后表现出显著的血管收缩 (流量和直径下降) (P < 0.001 流量,P = 0.046 直径).
- 糖尿病神经病变患者在刺激后没有显著减少臂动脉流量或直径;流量甚至增加.
- 这表明糖尿病神经病组对交感激活的血管收缩反应受损.
结论:
- 糖尿病神经病变与中型外围动脉中显著的血管运动功能障碍有关.
- 在患有糖尿病神经病变的个体中,对交感神经激活的生理血管收缩反应受损.
- 这些发现突出了可能导致糖尿病血管并发症的机制.
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