同时损失的纤毛基因WDR93和CFAP46在遗传学上遥远的鸟类
Buddhabhushan Girish Salve1, Amia Miriam Kurian1, Nagarjun Vijay1
1Computational Evolutionary Genomics Lab, Department of Biological Sciences, IISER Bhopal, Bhauri, Madhya Pradesh, India.
Royal Society open science
|August 25, 2023
概括
许多鸟类,包括和,都失去了WDR93基因,这是纤毛功能的一个关键组成部分. 这种损失,以及CFAP46,可能会影响它们对呼吸道病毒的易感性,并确定潜在的动物传播病毒库.
科学领域:
- 基因组学就是基因组学.
- 进化生物学 进化生物学
- 免疫学 免疫学 免疫学
背景情况:
- 呼吸系统是病原体的主要入口点.
- 由纤毛功能驱动的粘膜细胞清除是关键的先天防御.
- 病毒病原体可以破坏状细胞的功能,影响宿主防御.
研究的目的:
- 研究脊椎动物物种中WDR93基因的保存和丧失.
- 了解WDR93基因损失在宿主-病原体相互作用中的影响.
- 根据宿主防御基因状态来识别潜在的动物病源库.
主要方法:
- 对大约500个脊椎动物基因组进行比较基因组分析.
- 在七个分类类别和73个类别中进行了全系遗传学分析.
- 基因表达分析以确认基因丢失物种中没有WDR93转录.
主要成果:
- WDR93在脊椎动物中广泛存在,但在几个独立的鸟类 (陆地鸟类,) 中消失了.
- 鸟类的基因丢失与WDR93转录的缺失有关.
- 有WDR93损失的物种还表现出相关C1d组件CFAP46.6的大量细分缺失.
结论:
- 在某些鸟类中,WDR93和CFAP46的消失是影响天生的免疫力的重大进化事件.
- 了解这些基因损失可以提供对宿主-病原体动态的见解.
- 识别具有受损宿主防御基因的物种有助于病原体监测和动物病源库的识别.
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