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大麻素和四大麻素在帕金森病中的使用:一项观察性试点研究

Amber Sousa¹, Joanne DiFrancisco-Donoghue¹

¹Osteopathic Manipulative Medicine, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, USA.

|August 25, 2023

概括

像CBD和THC这样的大麻产品在帕金森病 (PD) 患者中表现出各种各样的效果,有些人报告症状缓解,但也经历了认知困难和嗜睡.

科学领域:

神经学神经学
药理学药理学是指药理学的学科.

背景情况:

在帕金森病 (PD) 中,大麻,四大麻 (THC) 和大麻 (CBD) 的使用越来越多,需要进一步研究.
对这些产品在PD患者的疗效和安全性的了解有限.

研究的目的:

检查使用,效果,副作用和对大麻使用的态度在PD患者的自然样本中.
调查CBD/THC对PD运动和非运动症状的影响.

主要方法:

对15名患有PD的个体进行横截面评估,将使用CBD/THC (n=8) 的人与对照组 (n=7) 进行比较.
利用结构化的神经心理测试,运动评估和情绪,认知和症状的问卷.
由于样本规模较小,使用了t测试,沙皮罗-威尔克和曼-惠特尼U分析.

主要成果:

观察到各种各样的处方产品,方法,感知益处和副作用.
CBD/THC使用者具有较低的全球认知能力 (MoCA分数),但具有相似的特定神经心理表现.
CBD/THC使用者报告了更多的非运动症状,疼痛,睡眠和焦虑的质量改善,以及嗜睡和忘记等副作用.

结论:

大麻 (CBD/THC) 在PD中的使用是多样化的,本研究中的用户显示较低的MoCA分数和更多的非运动症状.
报告的好处包括改善睡眠,焦虑和疼痛,但注意到了诸如认知困难等副作用.
未来的研究应该优先考虑使用标准化CBD/THC施用方法的临床试验.

关键词:

在Cannabidiol中使用.大麻素是一种大麻素.认知认知认知补充和替代药物补充和替代药物神经心理学神经心理学帕金森病是什么?帕金森病是什么?这是一种四化大麻醇 (tetrahydrocannabinol).

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