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选择性心血管标记物与结核病的关联:普杜切里社区探索性横截面分析研究
Premkumar Ramasubramani1, Sitanshu Sekhar Kar1, Sonali Sarkar1
1Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education & Research, Puducherry, IND.
Cureus
|August 25, 2023
概括
结核病 (TB) 患者,即使在完成治疗后,患心血管疾病 (CVD) 的风险也更高. 炎症标志物和动脉内膜介质厚度增加 (CIMT) 表明结核病和心血管疾病发展之间存在联系.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 免疫学 免疫学 免疫学
背景情况:
- 印度面临着结核病 (TB) 和非传染性疾病,包括心血管疾病 (CVD) 的双重负担.
- 有限的研究存在于结核病原和心血管疾病之间的关联.
- 了解这种联系对于高结核病负担地区的公共卫生至关重要.
研究的目的:
- 在新诊断的肺结核 (PTB) 患者,他们的家庭接触者 (HHC) 和完成治疗的PTB患者中调查心血管疾病 (CVD) 风险因素以及相关的免疫和放射性参数.
- 探索结核病患者炎症标志物和亚临床动脉样硬化之间的关系.
主要方法:
- 在城市普杜切里进行了一项试点横截面研究,比较了50名新诊断的PTB患者,50名年龄/性别匹配的HHC患者和50名完成治疗的PTB患者.
- 评估了心血管疾病风险因素,包括INF-γ,高灵敏性C反应蛋白 (hs-CRP) 和心动脉内膜介质厚度 (CIMT).
- 统计分析包括千平方,费舍尔精确,ANOVA和克鲁斯卡尔-瓦利斯测试.
主要成果:
- 新诊断和治疗完成的PTB患者的酒精摄入量较高. 过多的盐摄入量在新诊断的PTB患者中更为普遍.
- 在HHC和治疗完成的PTB患者中,肥胖率更高. 在新诊断的PTB患者中,IL-6水平升高.
- 在已经完成治疗的PTB患者中,INF-γ,hs-CRP和高内膜介质厚度 (CIMT) 是最常见的,这表明正在进行的炎症和动脉样硬化.
结论:
- 结核病患者的炎症标志物和高CIMT,即使在治疗后,表明结核病相关炎症和心血管风险之间存在潜在联系.
- 在接受过结核病治疗的人群中,心血管疾病风险仍然很高,这凸显了长期心血管监测的必要性.
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