白质过强度对PD患者认知功能的影响:一个元分析
Wenhao Zhao1, Bo Cheng1, Tao Zhu2
1Department of Neurology, Affiliated Hospital of Medical College, North Sichuan Medical College, Nanchong, China.
Frontiers in neurology
|August 25, 2023
概括
白质过强度 (WMH) 与帕金森病 (PD) 的认知衰退有关. 早期WMH可能标志着轻度认知障碍 (MCI) 的PD,有助于早期诊断和干预.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 帕金森病 (PD) 经常涉及认知功能障碍,这带来了重大挑战.
- 缺乏可靠的生物标志物用于早期检测PD相关的认知障碍.
- 关于白质过强度 (WMH) 和PD认知功能的先前研究显示了不一致的结果.
研究的目的:
- 进行关于WMH和PD患者认知功能之间的关联的元分析.
- 为了澄清WMH和帕金森病的认知衰退之间的关系.
主要方法:
- 在主要数据库 (PubMed,科学网,EMBASE,CNKI,CBM) 进行系统的文献搜索,截至2022年12月31日.
- 遵守PRISMA和MOOSE系统审查和元分析指南.
- 使用RevMan 5.3和Stata 15.0对23项涉及2,429名PD患者的研究数据进行统计分析.
主要成果:
- 患有PD和轻度认知障碍 (PD-MCI) 的患者的整体WMH水平明显高于正常认知 (PD-NC) 的患者.
- 在PD-MCI患者的周周结节 (PVH) 和深白质 (DWMH) 区域观察到WMH增加.
- 与没有痴呆症 (PDND) 患者相比,患有PD痴呆症 (PDD) 的患者的整体WMH负载显著更高,在各个子组中一致.
结论:
- 在帕金森病中,WMH与认知功能障碍显著相关.
- 存在WMH,特别是在早期阶段,可以作为PD与轻度认知障碍 (PD-MCI) 的指标.
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