相关实验视频
Updated: Aug 12, 2026

07:52
Conjunctival Commensal Isolation and Identification in Mice
Published on: May 1, 2021
4.5K
肠道微生物群和眼睛疾病:一项文献计量研究和可视化分析分析
Xiangyu Fu1,2, Haishan Tan1,2, Ling Huang1,2
1Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China.
Frontiers in cellular and infection microbiology
|August 25, 2023
概括
肠道微生物失生症越来越多地与眼睛疾病 (如卵膜炎和糖尿病视网膜病变) 有关. 准肠道微生物组显示出新治疗方法的前景,该领域的研究正在迅速扩大.
科学领域:
- 眼科医生 眼科 眼科
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 肠道微生物失生症是各种眼部疾病的日益增长的研究重点,包括紫外炎,与年龄相关的黄斑变性 (AMD),糖尿病视网膜病变 (DR),干眼,角膜炎和轨道病变.
- 准肠道微生物群正在成为这些眼睛疾病的重要治疗策略.
研究的目的:
- 绘制研究格局的地图,并通过图书法分析确定肠道微生物群和眼部疾病研究的新兴趋势和未来方向.
- 为了可视化全球研究成果,关键贡献者和在这个领域有影响力的出版物.
主要方法:
- 从2009年至2023年期间对284篇出版物的图书统计分析来源于科学网络核心集合.
- 包括CiteSpace和VOSviewer在内的可视化工具被用于分析国家分布,期刊重叠,关键字共同出现和作者/期刊共同引用网络.
主要成果:
- 自2016年以来,研究产出稳步增长,美国在出版物方面处于领先地位.
- 调查眼科和视觉科学是最著名的期刊. 关键词表明肠道微生物群,炎症和眼睛疾病之间存在很强的联系,例如卵膜炎,DR,AMD,干眼和Graves轨道病.
- 治疗策略如益生菌,饮食干预和便微生物移植被强调为未来研究的关键.
结论:
- 图书统计分析提供了关于研究热点和肠道微生物群在眼部疾病病原和治疗中的作用演变的全面概述.
- 这些发现突显了这一领域的动态性质及其结构关系,强调了针对微生物组的治疗的潜力.
相关概念视频
Microbiome of the Eye
The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Microbiota of the Large Intestine
The large intestine hosts the most densely populated microbial ecosystem in the human body. This complex community primarily consists of anaerobic bacteria, with Bacillota (formerly Firmicutes) and Bacteroidota (formerly Bacteroidetes) as the predominant groups. The distribution of these microbes varies along different sections of the large intestine, influenced by local environmental factors such as oxygen availability and nutrient composition.The cecum, located at the beginning of the large...
Dysbiosis of the Gut Microbiota
The human gut microbiome includes a diverse array of microbial species, including beneficial commensals and opportunistic pathogens, which interact to support host health. These microbes contribute to essential functions such as nutrient metabolism, immune system modulation, and maintenance of intestinal barrier integrity. However, disruptions to this equilibrium—referred to as dysbiosis—can have widespread physiological consequences.Dysbiosis is often characterized by reduced microbial...
Gut-Brain Axis
The gut–brain axis is a bidirectional communication system that connects the gastrointestinal tract and the brain. This interaction is mediated through multiple pathways, including the vagus nerve, hormonal signals, immune responses, and chemical messengers produced by gut microbes.Microbial Contributions to Brain FunctionGut microbiota contributes significantly to brain function by producing neuroactive compounds. These include neuroactive compounds that influence neurotransmitters such as...
Microbiota Modulation by Antibiotics
Antibiotics have revolutionized modern medicine by saving countless lives from bacterial infections. However, their widespread use has inadvertently harmed the delicate balance of the human gut microbiota. The gut microbiota, a complex community of bacteria, archaea, viruses, and fungi, plays a vital role in regulating metabolism, immune responses, and maintaining intestinal health. Antibiotics, especially broad-spectrum types, disrupt this ecosystem by eradicating both harmful and beneficial...

