整合进化,发育和生理上的不匹配
Paul E Griffiths1, Pierrick Bourrat2,1
1Department of Philosophy and Charles Perkins Centre, The University of Sydney, Sydney, Australia.
Evolution, medicine, and public health
|August 25, 2023
概括
进化医学通过整合进化不匹配和健康和疾病的发育起源 (DOHaD) 来解释疾病. 这一框架有助于了解环境变化如何通过生理和发育适应影响健康.
科学领域:
- 进化医学是一种进化医学.
- 发展生物学 发展生物学
- 生理学 生理学 生理学
背景情况:
- 进化不匹配,根植于适应性滞后,现在与健康和疾病的发育起源 (DOHaD) 范式集成.
- 这种融合统一了对健康和疾病的进化和发展观点.
- 之前的研究试图明确定义进化医学中的这一理论框架.
研究的目的:
- 为了清晰简单地呈现不匹配的整合理论.
- 促进不匹配理论在新研究领域的应用.
- 为不同形式的不匹配引入一致的术语.
主要方法:
- 对进化医学现有文献的综述.
- 从进化不匹配和DOHaD. 的概念合成.
- 为不匹配理论开发清晰的术语.
主要成果:
- 不匹配的整合理论解释了有机体如何适应跨规模的环境变化.
- 环境变化的适应性跟踪失败导致疾病.
- 不匹配是作为一个有效的概念来理解健康结果.
结论:
- 现代的不匹配概念是进化医学的一个有价值的框架.
- 它阐明了生理学,发育,进化和环境变化之间的相互作用.
- 这一框架有助于在不断变化的环境背景下解释健康结果.
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