在三级医院住院的儿童中扩散性气泡出血:一项追溯描述性研究
1Department of Paediatrics and Child Health, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa.
African journal of thoracic and critical care medicine
|August 25, 2023
概括
扩散膜出血 (DAH) 在儿童中很少见. 这项在南非的研究发现,大多数患有DAH的儿童对口服普雷尼松治疗反应良好,尽管资源有限,但结果是积极的.
科学领域:
- 儿科肺病学 儿科肺病学
- 罕见疾病 罕见疾病
- 血液学 血液学 血液学
背景情况:
- 扩散膜出血 (DAH) 是一种罕见的儿科疾病,在缺乏资源的环境中没有确立的管理指南.
- 本报告详细介绍了南非一家三级医院儿科DAH的临床特征,管理和结果.
研究的目的:
- 描述诊断为扩散膜出血 (DAH) 的儿童的临床特征,治疗方法和结果.
- 在资源有限的非洲环境中提供关于DAH管理的数据.
主要方法:
- 在克里斯·哈尼·巴拉格瓦纳特学术医院治疗DAH的15名儿童的案例系列.
- 临床表现分析,支气管支气管洗发现,肺活检,治疗方案和长期血红蛋白水平.
主要成果:
- 15名儿童中有11名 (73.3%) 患有严重的微细胞贫血.
- 在81.8%的病例中,支气管支气管洗显示出含有血红素的巨细胞;在60%的病例中,肺部活检显示出毛细血管炎.
- 15名儿童中有9名 (60%) 在接受口服普得尼松和补充疗法治疗一年后达到正常的血红蛋白水平.
结论:
- 扩散膜出血在儿童中不常见,与之前的报道一致.
- 在这个系列中,绝大多数儿童DAH患者对口服普得尼松治疗反应良好,即使资源有限.
- 建议进行进一步的国家审计,以确定南非DAH的发病率,并为南非DAH的管理策略提供信息.
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